ArticleEnvironmental health : a global access science source2016
In utero exposure to polychlorinated biphenyls is associated with decreased fecundability in daughters of Michigan female fisheaters: a cohort study.
Article in Environmental health : a global access science source, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Persistent organic pollutants and couple fecundability: a systematic review.Human reproduction update · 2021Pooled it
- Dioxin exposure associated with fecundability and infertility in mothers and daughters of Seveso, Italy.Human reproduction (Oxford, England) · 2021Article
- Transgenerational Effects of Endocrine-Disrupting Chemicals on Male and Female Reproduction.Endocrinology · 2019Review
- Transgenerational effects of polychlorinated biphenyls: 1. Development and physiology across 3 generations of rats.Environmental health : a global access science source · 2018Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMultiple studies have suggested a relationship between adult exposures to environmental organochlorines and fecundability. There is a paucity of data, however, regarding fetal exposure to organochlorines via the mother's blood and fecundability of adult female offspring.
methodsData from a two-generation cohort of maternal fisheaters was investigated to assess female offspring fecundability. Serum concentrations of polychlorinated biphenyls (PCBs) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (DDE) in Michigan female anglers were serially measured between 1973 and 1991 and used to estimate in utero exposure in their female offspring using two different methods. The angler cohort included 391 women of whom 259 provided offspring information. Of 213 daughters aged 20-50, 151 participated (71 %) and provided information for time intervals of unprotected intercourse (TUI). The daughters reported 308 TUIs (repeated observations), of which 288 ended in pregnancy. We estimated the fecundability ratio (FR) for serum-PCB and serum-DDE adjusting for confounders and accounting for repeated measurements. An FR below one indicates a longer time to pregnancy.
resultsCompared to serum-PCB of <2.5 μg/L, the FR was 0.60 for serum-PCB between 2.5-7.4 μg/L [95 % confidence intervals (CI) 0.36, 0.99], and 0.42 [95 % CI 0.20, 0.88] for serum-PCB >7.4 μg/L. Similar results were obtained using the alternative statistical method to estimate in utero serum-PCB. The association was stronger for TUIs when women planned a baby; FR = 0.50 for serum-PCB between 2.5-7.4 μg/L, [95 % CI 0.29, 0.89], and 0.30 [95 % CI 0.13, 0.68] for serum-PCB >7.4 μg/L. There was no relationship between in utero exposure to DDE and fecundability in daughters.
conclusionsDecreased fecundability in female offspring of fisheaters was found to be associated with PCB exposure in utero, possibly related to endocrine disruption in the oocyte and/or other developing organs influencing reproductive capacity in adulthood.
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