Evidence map›Paper›PMID 27576461›Full record

ReviewJournal of leukocyte biology2017

Inflammatory properties of antibiotic-treated bacteria.

Andrea J Wolf, George Y Liu, David M Underhill

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. The Journal of biological chemistry · 2020
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Andrea J WolfF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
George Y LiuDivision of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA; and.
David M UnderhillF. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA; david.underhill@csmc.edu.
Cedars-Sinai Medical Center · US

Funding

Phagosomal targeting of CARD proteinsR01GM085796 · NIGMS · CEDARS-SINAI MEDICAL CENTER · PI UNDERHILL, DAVID M. · 2008 to 2020
$4.1M
Impact of Antibiotics and PBP2a on the Immunopathology of MRSA pneumoniaR21AI097741 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI LIU, GEORGE Y, UNDERHILL, DAVID M. · 2012 to 2013
$439k
NIAID NIH HHS R21 AI097741NIGMS NIH HHS R01 GM085796
6 · The paper itself

Abstract

Antibiotics have proven to be enormously effective tools in combating infectious diseases. A common roadblock to the effective use of antibiotics is the development of antibiotic resistance. We have recently observed that the very mechanism by which methicillin-resistant Staphylococcus aureus (MRSA) becomes antibiotic resistant causes the organism to be more inflammatory to innate immune cells. In this review, we offer some thoughts on the ways in which antibiotics have been observed to influence immune responses to bacteria.

Indexed as

AnimalsAnti-Bacterial AgentsBacteriaCell WallHumansInflammationMicrobial Sensitivity TestsMicrobial ViabilityAnti-Bacterial AgentsautolysispeptidoglycanStaphylococcus aureusβ-lactam

Identifiers

PMID27576461
PMCPMC5166437
OpenAlexW2516537187

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.