ArticlePediatric radiology2016
Quantitative CT characterization of pediatric lung development using routine clinical imaging.
Article in Pediatric radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Assessing the feasibility of neonatal chest MRI for bronchopulmonary dysplasia using a standard 1.5-Tesla scanner.European radiology · 2026Article
- Identifying Predictors of Lung Volume in Pediatric Patients Undergoing Surgery: A STROBE-Compliant Retrospective Cross-Sectional Chest Computed Tomography Study.Journal of clinical medicine · 2026Article
- Case Report: Surgical management of thoracic chondrodysplasia in children: complete mobile thoracic replacement.Frontiers in surgery · 2026Article
- Normative values for lung, bronchial sizes, and bronchus-artery ratios in chest CT scans: from infancy into young adulthood.European radiology · 2025Article
- Physiologically based modeling reveals different risk of respiratory depression after fentanyl overdose between adults and children.Clinical and translational science · 2024Article
- PediatricJournal of magnetic resonance imaging : JMRI · 2022Article
- Low- and High-Attenuation Lung Volume in Quantitative Chest CT in Children without Lung Disease.Children (Basel, Switzerland) · 2021Article
- Computed tomography based measurements to evaluate lung density and lung growth after congenital diaphragmatic hernia.Scientific reports · 2021Article
- Lung density analysis using quantitative computed tomography in children with pectus excavatum.Polish journal of radiology · 2021Article
- Automatic lung segmentation in routine imaging is primarily a data diversity problem, not a methodology problem.European radiology experimental · 2020Article
- Quantitative Assessment of Parenchymal Involvement Using 3D Lung Model in Adolescent With Covid-19 Interstitial Pneumonia.Frontiers in pediatrics · 2020Article
- From infancy to adulthood-Developmental changes in pulmonary quantitative computed tomography parameters.PloS one · 2020Article
- Quantitative CT and pulmonary function in children with post-infectious bronchiolitis obliterans.PloS one · 2019Article
- Assessment of pulmonary structure-function relationships in young children and adolescents with cystic fibrosis by multivolume proton-MRI and CT.Journal of magnetic resonance imaging : JMRI · 2018Article
- Lung Clearance Index and Quantitative Computed Tomography of Post-Infectious Bronchiolitis Obliterans in Infants.Scientific reports · 2017Article
- Quantification of neonatal lung parenchymal density via ultrashort echo time MRI with comparison to CT.Journal of magnetic resonance imaging : JMRI · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe use of quantitative CT analysis in children is limited by lack of normal values of lung parenchymal attenuation. These characteristics are important because normal lung development yields significant parenchymal attenuation changes as children age.
objectiveTo perform quantitative characterization of normal pediatric lung parenchymal X-ray CT attenuation under routine clinical conditions in order to establish a baseline comparison to that seen in pathological lung conditions. MATERIALS AND
methodsWe conducted a retrospective query of normal CT chest examinations in children ages 0-7 years from 2004 to 2014 using standard clinical protocol. During these examinations semi-automated lung parenchymal segmentation was performed to measure lung volume and mean lung attenuation.
resultsWe analyzed 42 CT examinations in 39 children, ages 3 days to 83 months (mean ± standard deviation [SD] = 42 ± 27 months). Lung volume ranged 0.10-1.72 liters (L). Mean lung attenuation was much higher in children younger than 12 months, with values as high as -380 Hounsfield units (HU) in neonates (lung volume 0.10 L). Lung volume decreased to approximately -650 HU by age 2 years (lung volume 0.47 L), with subsequently slower exponential decrease toward a relatively constant value of -860 HU as age and lung volume increased.
conclusionNormal lung parenchymal X-ray CT attenuation decreases with increasing lung volume and age; lung attenuation decreases rapidly in the first 2 years of age and more slowly thereafter. This change in normal lung attenuation should be taken into account as quantitative CT methods are translated to pediatric pulmonary imaging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.