ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2016
Quantifying target-specific motion in anal cancer patients treated with intensity modulated radiotherapy (IMRT).
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Optimising chemoradiotherapy in anal cancer.ESMO gastrointestinal oncology · 2026Review
- Innovative radiotherapy approaches.ESMO gastrointestinal oncology · 2026Review
- Setup and target volume shape variation in rectal cancer radiotherapy: a systematic literature review.Technical innovations & patient support in radiation oncology · 2026Review
- Individual lymph node position variation for rectal cancer patients treated with long course chemoradiotherapy.Physics and imaging in radiation oncology · 2024Article
- Management of locally advanced anal canal carcinoma with intensity-modulated radiotherapy and concurrent chemotherapy.Medical oncology (Northwood, London, England) · 2018Review
- Target volume motion during anal cancer image guided radiotherapy using cone-beam computed tomography.The British journal of radiology · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
background and purposeIntensity modulated radiotherapy requires all target areas to be treated by a single radiotherapy plan. In anal cancer, the pelvic nodes, inguinal nodes and primary tumour represent three different targets. We aim to calculate target-specific motion in anal cancer radiotherapy, when delivered using a single pelvic online auto-match. MATERIALS AND
methodsTwenty consecutive patients treated using IMRT at a single institution were studied. CBCTs were retrospectively re-matched around the inguinal nodes and primary tumour. Match values were recorded relative to origin, defined as pelvic CBCT auto-match. Systematic and random errors were quantified to determine target-specific motion and suggested margins calculated using van Herk formulae.
resultsThe suggested margins to cover the independent motion of the inguinal and anal targets for LR, CC and AP set up around the inguinal nodes were 1.5mm, 2.7mm and 2.8mm; and the primary tumour were, 4.6mm, 8.9mm and 5.2mm respectively.
conclusionsTarget-specific set up will likely result in reduced treatment volumes and as such reduced toxicity. This is the first time a relationship has been described between pelvic bones, inguinal nodes and primary tumour. The PLATO study will prospectively assess the toxicity and outcomes of this target-specific margins strategy.
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