Evidence map›Paper›PMID 27575818›Full record

ArticleBioengineered2016

Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats.

Ou Zeng, Fang Li, Yan Li, Lin Li, Ting Xiao, Chun Chu, Jun Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Diabetic Nephropathy and Gaseous Modulators.Antioxidants (Basel, Switzerland) · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Podocytes and microRNA-30/Cx43 axis in diabetic nephropathy.Annals of translational medicine · 2021
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ou Zenga Department of Geriatrics , The First Affiliated Hospital of University of South China , Hengyang , Hunan , China.
Fang Lia Department of Geriatrics , The First Affiliated Hospital of University of South China , Hengyang , Hunan , China.
Yan Lia Department of Geriatrics , The First Affiliated Hospital of University of South China , Hengyang , Hunan , China.
Lin Lia Department of Geriatrics , The First Affiliated Hospital of University of South China , Hengyang , Hunan , China.
Ting Xiaoa Department of Geriatrics , The First Affiliated Hospital of University of South China , Hengyang , Hunan , China.
Chun Chub Department of Pharmacy , The Second Affiliated Hospital of University of South China , Hengyang , Hunan , China.
Jun Yanga Department of Geriatrics , The First Affiliated Hospital of University of South China , Hengyang , Hunan , China.
First Affiliated Hospital of University of South China · CNUniversity of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the effects of hydrogen sulfide (H

methodSD rats were divided into 4 groups randomly: control group(n = 12), STZ group (n = 12), STZ+ H2S group (n = 12), and H

resultsCompared with the control group, collagen accumulation was markedly enhanced, and the content of type II collagen, kidney hydroxyproline and timp-2 were boosted in STZ group mice (P < 0.01), while the expressions of CX40,CX43, CX45, MMP-1 and MMP-2 were obviously deceased (P < 0.01). Compared with STZ group, the expressions of CX40, CX43, CX45, MMP-1 and MMP-2 were significantly increased (P < 0.01), while the content of type II collagen, kidney hydroxyproline and timp-2 expression were markedly deceased in STZ+H

conclusionH

Indexed as

AnimalsBlood GlucoseCollagen Type IIConnexin 43ConnexinsDiabetes Mellitus, ExperimentalDown-RegulationFibrosisGasotransmittersHydrogen SulfideHydroxyprolineImmunohistochemistryKidneyMatrix Metalloproteinase 1Matrix Metalloproteinase 2RatsBlood GlucoseCollagen Type IIConnexin 43ConnexinsGasotransmittersGja1 protein, ratHydrogen SulfideHydroxyprolineMatrix Metalloproteinase 1Matrix Metalloproteinase 2MMP1 protein, ratMmp2 protein, ratTissue Inhibitor of Metalloproteinase-2connexindiabeticfibrosishydrogen sulfiderenal

Identifiers

PMID27575818
PMCPMC5060972
OpenAlexW2509447990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.