ArticleEnvironment international2016
Altered fine motor function at school age in Inuit children exposed to PCBs, methylmercury, and lead.
Article in Environment international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Statement on the findings presented in the Toxicological Profile for Mercury issued by the US ATSDR.EFSA journal. European Food Safety Authority · 2026Article
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- Neuromotor effects of early-life exposure to a mixture of endocrine disruptors in Belgian preschool children.Environmental health : a global access science source · 2025Article
- Effects of 28-day nose-only inhalation of PCB52 (2,2',5,5'-Tetrachlorobiphenyl) on the brain transcriptome.Toxicology · 2024Article
- Sources of exposure to lead in Arctic and subarctic regions: a scoping review.International journal of circumpolar health · 2023Article
- Postnatal methylmercury exposure and neurodevelopmental outcomes at 7 years of age in the Seychelles Child Development Study Nutrition Cohort 2.Neurotoxicology · 2023Article
- Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children.Brain sciences · 2023Review
- Article
- Article
- Neurobehavioural and cognitive effects of prenatal exposure to organochlorine compounds in three year old children.BMC pediatrics · 2021Article
- Identification of Arctic Food Fish Species for Anthropogenic Contaminant Testing Using Geography and Genetics.Foods (Basel, Switzerland) · 2020Article
- Human Health and Ocean Pollution.Annals of global health · 2020Review
- Ahr and Cyp1a2 genotypes both affect susceptibility to motor deficits following gestational and lactational exposure to polychlorinated biphenyls.Neurotoxicology · 2018Article
- Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Neurodevelopmental Effects of Mercury.Advances in neurotoxicology · 2018Article
- Gestational and early childhood air pollution exposure and neurodevelopmental outcomes in early childhood.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMotor deficits have frequently been reported in methylmercury (MeHg) poisoning in adults. However, whether exposure to neurotoxic contaminants from environmental sources early in life is associated with neuromotor impairments has received relatively little attention. This study examines the relation of developmental exposure to MeHg, polychlorinated biphenyls (PCBs), and lead to motor function in school-age Inuit children exposed through their traditional diet.
methodsIn a prospective study in Nunavik, children (mean age=11.3years) were assessed on a battery of fine motor tasks, namely the Stanford-Binet Copying subtest (N=262), the Santa Ana Form Board, and the Finger Tapping Test (N=215). The relation of mercury (Hg; as an index of MeHg exposure), PCB congener 153 (PCB153), and lead concentrations in cord and current blood samples to task performance was examined using linear regression analyses.
resultsAfter adjustment for potential confounders and control for the other contaminants, higher current PCB concentrations were associated with poorer Santa Ana Form Board and Finger Tapping performance. Results were virtually identical when PCB153 was replaced by other PCB congeners. Higher current Hg levels were independently associated with poorer Finger Tapping performance.
conclusionsThis is the first prospective longitudinal study in children to provide evidence of neuromotor impairments associated with postnatal exposure to seafood contaminants from environmental sources. Fine motor speed appears particularly sensitive to the effects of postnatal PCB exposure, which is unusually high in this population. Results with postnatal MeHg are concordant with previous cross-sectional studies with children and adults.
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