ArticleAnnals of vascular surgery2017
Coronary Exercise Hyperemia Is Impaired in Patients with Peripheral Arterial Disease.
Article in Annals of vascular surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Peripheral artery disease causes consistent gait irregularities regardless of the location of leg claudication pain.Annals of physical and rehabilitation medicine · 2024Trial
- Eight weeks of nitrate supplementation improves blood flow and reduces the exaggerated pressor response during forearm exercise in peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2018Trial
- Beta-1 vs. beta-2 adrenergic control of coronary blood flow during isometric handgrip exercise in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Oxidative damage in the gastrocnemius predicts long-term survival in patients with peripheral artery disease.npj aging · 2024Article
- Effects of short-term dietary nitrate supplementation on exercise and coronary blood flow responses in patients with peripheral artery disease.Frontiers in nutrition · 2024Article
- Aortic blood pressure and pulse wave indices responses to exercise in peripheral artery disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Impaired microcirculatory function, mitochondrial respiration, and oxygen utilization in skeletal muscle of claudicating patients with peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2022Article
- Article
- Association of severity of coronary artery disease by SYNTAX score (SS) and lower extremity arterial disease by duplex ultrasound (DUS) study-an Indian perspective.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2020Article
- Thromboxane AAmerican journal of physiology. Heart and circulatory physiology · 2020Article
- Systemic and regional hemodynamic response to activation of the exercise pressor reflex in patients with peripheral artery disease.American journal of physiology. Heart and circulatory physiology · 2020Article
- Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise.American journal of physiology. Heart and circulatory physiology · 2020Review
- The exercise pressor reflex and active OPhysiological reports · 2019Article
- Quantification of Daily Physical Activity and Sedentary Behavior of Claudicating Patients.Annals of vascular surgery · 2019Article
- Peripheral revascularization attenuates the exercise pressor reflex and increases coronary exercise hyperemia in peripheral arterial disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Blood pressure and leg deoxygenation are exaggerated during treadmill walking in patients with peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Blood pressure and calf muscle oxygen extraction during plantar flexion exercise in peripheral artery disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPeripheral arterial disease (PAD) is an atherosclerotic vascular disease that affects over 200 million people worldwide. The hallmark of PAD is ischemic leg pain and this condition is also associated with an augmented blood pressure response to exercise, impaired vascular function, and high risk of myocardial infarction and cardiovascular mortality. In this study, we tested the hypothesis that coronary exercise hyperemia is impaired in PAD.
methodsTwelve patients with PAD and no overt coronary disease (65 ± 2 years, 7 men) and 15 healthy control subjects (64 ± 2 years, 9 men) performed supine plantar flexion exercise (30 contractions/min, increasing workload). A subset of subjects (n = 7 PAD, n = 8 healthy) also performed isometric handgrip exercise (40% of maximum voluntary contraction to fatigue). Coronary blood velocity in the left anterior descending artery was measured by transthoracic Doppler echocardiography; blood pressure and heart rate were monitored continuously.
resultsCoronary blood velocity responses to 4 min of plantar flexion exercise (PAD: Δ2.4 ± 1.2, healthy: Δ6.0 ± 1.6 cm/sec, P = 0.039) and isometric handgrip exercise (PAD: Δ8.3 ± 4.2, healthy: Δ16.9 ± 3.6, P = 0.033) were attenuated in PAD patients.
conclusionThese data indicate that coronary exercise hyperemia is impaired in PAD, which may predispose these patients to myocardial ischemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.