ArticlePhysical review. E2016
Role of catch bonds in actomyosin mechanics and cell mechanosensitivity.
Article in Physical review. E, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Dynamic mechanisms for membrane skeleton transitions.Journal of cell science · 2025Article
- A mechanochemical model recapitulates distinct vertebrate gastrulation modes.Science advances · 2023Article
- Light-driven biological actuators to probe the rheology of 3D microtissues.Nature communications · 2023Article
- Actomyosin contractility and buckling of microtubules in nucleation, growth and disassembling of focal adhesions.Biomechanics and modeling in mechanobiology · 2022Article
- Epithelial cells fluidize upon adhesion but display mechanical homeostasis in the adherent state.Biophysical journal · 2022Article
- Detailed Balance Broken by Catch Bond Kinetics Enables Mechanical-Adaptation in Active Materials.Advanced functional materials · 2021Article
- Focus on time: dynamic imaging reveals stretch-dependent cell relaxation and nuclear deformation.Biophysical journal · 2021Article
- Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis inDevelopment (Cambridge, England) · 2019Article
- Computational modeling of the large deformation and flow of viscoelastic polymers.Computational mechanics · 2019Article
- Thermodynamic Modeling of the Statistics of Cell Spreading on Ligand-Coated Elastic Substrates.Biophysical journal · 2018Article
- How do fire ants control the rheology of their aggregations? A statistical mechanics approach.Journal of the Royal Society, Interface · 2018Article
- The Chain Distribution Tensor: Linking Nonlinear Rheology and Chain Anisotropy in Transient Polymers.Polymers · 2018Article
- Theoretical Analysis of Stress Distribution and Cell Polarization Surrounding a Model Wound.Biophysical journal · 2018Article
- Transient response of nonlinear polymer networks: A kinetic theory.Journal of the mechanics and physics of solids · 2018Article
- Heterogeneity is key to hydrogel-based cartilage tissue regeneration.Soft matter · 2017Article
- Structural Modeling of Mechanosensitivity in Non-Muscle Cells: Multiscale Approach to Understand Cell Sensing.ACS biomaterials science & engineering · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We propose a mechanism of adherent cell mechanosensing, based on the idea that the contractile actomyosin machinery behaves as a catch bond. For this, we construct a simplified model of the actomyosin structure that constitutes the building block of stress fibers and express the stability of cross bridges in terms of the force-dependent bonding energy of the actomyosin bond. Consistent with experimental measurements, we then consider that the energy barrier of the actomyosin bond increases for tension and show that this response is enough to explain the force-induced stabilization of a stress fiber. Further numerical simulations at the cellular level show that the catch-bond hypothesis can help in understanding and predict the sensitivity of adherent cells to substrate stiffness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.