ArticleEndocrinology2016
Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development.
Open access · bronzeAbstract read
In one paragraph
Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The expression of insulin signaling and N-methyl-D-aspartate receptor genes in areas of gray matter atrophy is associated with cognitive function in type 2 diabetes.Journal of Alzheimer's disease : JAD · 2025Article
- Isorhamnetin Ameliorates Non-Esterified Fatty Acid-Induced Apoptosis, Lipid Accumulation, and Oxidative Stress in Bovine Endometrial Epithelial Cells via Inhibiting the MAPK Signaling Pathway.Antioxidants (Basel, Switzerland) · 2025Article
- PPAR Gamma and Viral Infections of the Brain.International journal of molecular sciences · 2021Review
- Role of the Peroxisome Proliferator Activated Receptors in Hypertension.Circulation research · 2021Review
- Central Neurocircuits Regulating Food Intake in Response to Gut Inputs-Preclinical Evidence.Nutrients · 2021Review
- Behavioral Feeding Circuit: Dietary Fat-Induced Effects of Inflammatory Mediators in the Hypothalamus.Frontiers in endocrinology · 2020Review
- RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity.The Journal of clinical investigation · 2019Article
- PPARs and Energy Metabolism Adaptation during Neurogenesis and Neuronal Maturation.International journal of molecular sciences · 2018Review
- Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis.International journal of molecular sciences · 2018Review
- Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism.JCI insight · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Madeliene StumpMedical Scientist Training Program (M.S., K.R., C.D.S.); Neuroscience Graduate Program (M.S.); Departments of Pharmacology (D.-F.G., K.-T.L., M.M., K.R., C.D.S.), Anatomy and Cell Biology (M.D.C.), and Pediatrics (A.W.N.); and University of Iowa Healthcare Center for Hypertension Research (K.R., C.D.S.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Deng-Fu GuoMedical Scientist Training Program (M.S., K.R., C.D.S.); Neuroscience Graduate Program (M.S.); Departments of Pharmacology (D.-F.G., K.-T.L., M.M., K.R., C.D.S.), Anatomy and Cell Biology (M.D.C.), and Pediatrics (A.W.N.); and University of Iowa Healthcare Center for Hypertension Research (K.R., C.D.S.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Ko-Ting LuMedical Scientist Training Program (M.S., K.R., C.D.S.); Neuroscience Graduate Program (M.S.); Departments of Pharmacology (D.-F.G., K.-T.L., M.M., K.R., C.D.S.), Anatomy and Cell Biology (M.D.C.), and Pediatrics (A.W.N.); and University of Iowa Healthcare Center for Hypertension Research (K.R., C.D.S.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Masashi MukohdaMedical Scientist Training Program (M.S., K.R., C.D.S.); Neuroscience Graduate Program (M.S.); Departments of Pharmacology (D.-F.G., K.-T.L., M.M., K.R., C.D.S.), Anatomy and Cell Biology (M.D.C.), and Pediatrics (A.W.N.); and University of Iowa Healthcare Center for Hypertension Research (K.R., C.D.S.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Martin D CassellMedical Scientist Training Program (M.S., K.R., C.D.S.); Neuroscience Graduate Program (M.S.); Departments of Pharmacology (D.-F.G., K.-T.L., M.M., K.R., C.D.S.), Anatomy and Cell Biology (M.D.C.), and Pediatrics (A.W.N.); and University of Iowa Healthcare Center for Hypertension Research (K.R., C.D.S.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Andrew W NorrisMedical Scientist Training Program (M.S., K.R., C.D.S.); Neuroscience Graduate Program (M.S.); Departments of Pharmacology (D.-F.G., K.-T.L., M.M., K.R., C.D.S.), Anatomy and Cell Biology (M.D.C.), and Pediatrics (A.W.N.); and University of Iowa Healthcare Center for Hypertension Research (K.R., C.D.S.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Kamal RahmouniMedical Scientist Training Program (M.S., K.R., C.D.S.); Neuroscience Graduate Program (M.S.); Departments of Pharmacology (D.-F.G., K.-T.L., M.M., K.R., C.D.S.), Anatomy and Cell Biology (M.D.C.), and Pediatrics (A.W.N.); and University of Iowa Healthcare Center for Hypertension Research (K.R., C.D.S.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
Curt D SigmundMedical Scientist Training Program (M.S., K.R., C.D.S.); Neuroscience Graduate Program (M.S.); Departments of Pharmacology (D.-F.G., K.-T.L., M.M., K.R., C.D.S.), Anatomy and Cell Biology (M.D.C.), and Pediatrics (A.W.N.); and University of Iowa Healthcare Center for Hypertension Research (K.R., C.D.S.), Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242.
University of Iowa · USSociety for Neuroscience · US
Funding
Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2MVascular Protection During HypertensionP01HL062984 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2000 to 2015
$22.2MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9MEarly Pathogenesis of Cystic Fibrosis Related DiabetesR24DK096518 · NIDDK · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F, MORAN, ANTOINETTE M. · 2012 to 2018
$10.1MFatty Acid Defects & Oxidative Stress Modulate Islet Function in Cystic FibrosisR01DK097820 · NIDDK · UNIVERSITY OF IOWA · PI NORRIS, ANDREW W, UC, ALIYE · 2012 to 2016
$1.9MRole of PPARG the PPARG Target Gene RBP7 in the EndotheliumR01HL131689 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2016 to 2018
$1.9MHypertension: Role of Smooth Muscle Cullin-3 and the CRL3 ComplexR01HL125603 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2015 to 2018
$1.7MNHLBI NIH HHS P01 HL062984NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL125603NHLBI NIH HHS R01 HL131689NIDDK NIH HHS R01 DK097820NIDDK NIH HHS R24 DK096518NIGMS NIH HHS T32 GM007337
Abstract
Peroxisome proliferator activated receptor (PPARγ) is a nuclear receptor transcription factor that regulates adipogenesis and energy homeostasis. Recent studies suggest PPARγ may mediate some of its metabolic effects through actions in the brain. We used a Cre-recombinase-dependent (using Nestin
Indexed as
AdipogenesisAnimalsBody CompositionBrainDiet, High-FatEnergy MetabolismFastingGlucoseGlucose Tolerance TestHumansInsulinInsulin-Like Growth Factor IInsulin ResistanceMaleMiceMice, TransgenicGlucoseInsulinInsulin-Like Growth Factor IPPAR gammaReceptor, Insulin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.