Evidence map›Paper›PMID 27574999›Full record

Trial reportThe Journal of pediatrics2016

Neonatal Resuscitation with an Intact Cord: A Randomized Clinical Trial.

Anup Katheria, Debra Poeltler, Jayson Durham, Jane Steen, Wade Rich, Kathy Arnell, Mauricio Maldonado, Larry Cousins, Neil Finer

4 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 73 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 4 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02231411 nacompletednot on this map

Neonatal Resuscitation With Intact Cord

TypeinterventionalSponsorSharp HealthCareRan2014 to 2016Enrolled150ConditionsIntraventricular HemorrhageArmsV-DCC, Delayed cord clamping, Dry and and if apneic initially can stimulate by gently rubbing the back for approximately 30 seconds with warm sterile towels
NCT03242044 nacompletednot on this mapstarted 2018, after this paper: background citation

Resuscitation of Infants With Congenital Diaphragmatic Hernia With an Intact Umbilical Cord

TypeinterventionalSponsorUniversity of Colorado, DenverRan2018 to 2020Enrolled10ConditionsCongenital Diaphragmatic HerniaArmsCongenital diaphragmatic hernia resuscitation with an intact umbilical cord
NCT04413097 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants

TypeinterventionalSponsorSharp HealthCareRan2021 to 2026Enrolled140ConditionsIVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, HyperoxiaArmsDelayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
NCT06408376 narecruitingnot on this mapstarted 2022, after this paper: background citation

Physiological Umbilical Cord Clamping in Patients With Congenital Diaphragmatic Hernia. Clinical Trial

TypeinterventionalSponsorHospital JP GarrahanRan2022 to 2026Enrolled80ConditionsUmbilical Cord Clamping, Congenital Diaphragmatic Hernia, Delayed Umbilical Cord SeparationArmsPhysiological cord clamping
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 4 syntheses or guidelines pooled it, 154 citations in OpenAlex.

  1. Pooled it
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  5. Trial
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  12. Randomised trial of cord clamping and initial stabilisation at very preterm birth.Archives of disease in childhood. Fetal and neonatal edition · 2018
    Trial
  13. Article
  14. Care of the Newborn and Cord During the Third Stage of Labour (Scientific Impact Paper No. 78).BJOG : an international journal of obstetrics and gynaecology · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Factors associated with rates and durations of cord clamping practice compliance in preterm neonates of <33 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  19. How Delayed Cord Clamping Saves Newborn Lives.Children (Basel, Switzerland) · 2025
    Review
  20. Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Anup KatheriaNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA. Electronic address: anup.katheria@sharp.com.
Debra PoeltlerNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Jayson DurhamNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Jane SteenNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Wade RichNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Kathy ArnellNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Mauricio MaldonadoNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Larry CousinsNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Neil FinerNeonatal Research Institute, Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA.
Sharp Mary Birch Hospital for Women & Newborns · US

Funding

Neonatal Resuscitation with Intact Cord (NRIC)R21HD080594 · NICHD · SHARP MEMORIAL HOSPITAL · PI KATHERIA, ANUP C · 2014 to 2015
$348k
NICHD NIH HHS R21 HD080594
6 · The paper itself

Abstract

objectiveTo assess whether providing ventilation during delayed cord clamping (V-DCC) increases placental transfusion compared with delayed cord clamping alone (DCC only). STUDY

designInborn premature infants (23

resultsThere was no difference in the primary outcome of peak hematocrit in the first 24 hours of life. The onset of breathing was similar between both groups (25 ± 20 and 27 ± 28 seconds, P = .627); however, infants receiving DCC received a greater duration of stimulation than V-DCC (41 ± 19 and 20 ± 21 seconds P = .002). There were no differences in delivery room interventions, early hemodynamics (cerebral oxygenation by near-infrared spectroscopy, cardiac output and stroke volume by electrical cardiometry, or superior vena cava flow by of functional echocardiography), or neonatal outcomes.

conclusionsV-DCC was feasible but did not lead to any measurable clinical improvements immediately after delivery or reduce subsequent neonatal morbidity. Caretakers should consider providing adequate stimulation before cord clamping.

trial registrationClinicalTrials.gov: NCT02231411.

Indexed as

ConstrictionDelivery, ObstetricEchocardiographyFemaleHematocritHemodynamicsHumansInfant, NewbornInfant, PrematureMalePlacentaPositive-Pressure RespirationPregnancySpectroscopy, Near-InfraredTime FactorsUmbilical Cordcesarean deliverydelayed cord clampingintraventricular hemorrhageresuscitation

Identifiers

PMID27574999
PMCPMC5527831
OpenAlexW2509347230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.