ArticleJournal of pediatric gastroenterology and nutrition2016
Pilot Study of Functional Magnetic Resonance Imaging Responses to Somatic Pain Stimuli in Youth With Functional and Inflammatory Gastrointestinal Disease.
Article in Journal of pediatric gastroenterology and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Mapping the neuroimaging landscape of inflammatory bowel disease: a bibliometric analysis and systematic scoping review.Frontiers in neuroscience · 2026Pooled it
- Silent Struggles Within: Alexithymia Unveiled in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.Journal of neurogastroenterology and motility · 2024Pooled it
- Alexithymia and Inflammatory Bowel Disease: A Systematic Review.Frontiers in psychology · 2020Pooled it
- Pooled it
- Interoceptive Processing in Functional Gastrointestinal Disorders.International journal of molecular sciences · 2024Review
- Alexithymia impairs quality of life in irritable bowel syndrome.Future science OA · 2023Article
- Distinct Alterations in Central Pain Processing of Visceral and Somatic Pain in Quiescent Ulcerative Colitis Compared to Irritable Bowel Syndrome and Health.Journal of Crohn's & colitis · 2023Article
- Brain regulation of gastric dysfunction induced by stress.Nature metabolism · 2023Article
- An examination of resting-state functional connectivity in patients with active Crohn's disease.Frontiers in neuroscience · 2023Article
- Altered Brain Structure in Chronic Visceral Pain: Specific Differences in Gray Matter Volume and Associations With Visceral Symptoms and Chronic Stress.Frontiers in neurology · 2021Article
- Interrogating the Gut-Brain Axis in the Context of Inflammatory Bowel Disease: A Translational Approach.Inflammatory bowel diseases · 2020Review
- Aberrant Brain Function in Active-Stage Ulcerative Colitis Patients: A Resting-State Functional MRI Study.Frontiers in human neuroscience · 2019Article
- Brain-Gut Axis: Clinical Implications.Gastroenterology clinics of North America · 2018Review
- Association Between Alexithymia and Functional Gastrointestinal Disorders.Frontiers in psychology · 2018Article
- Alexithymic characteristics and interoceptive abilities are associated with disease severity and levels of C-reactive protein and cytokines in patients with inflammatory bowel disease.Annals of gastroenterologyArticle
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundBrain-gut axis signaling modifies gastrointestinal symptomatology. Altered neural processing of intestinal pain signals involves interoceptive brain regions in adults with functional and inflammatory gastrointestinal disorders. Although these disorders frequently present in childhood, there are no published studies in youth. We determined whether neural processing of somatic pain stimuli differs in adolescents and young adults (AYA) with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), as compared to healthy controls (HC).
methodsIBS and IBD AYA (16-20 years) underwent anticipated and thermal pain stimuli of low and high intensity on their forearm and simultaneous blood oxygen level-dependent functional magnetic resonance imaging. Data from adult HC were used for comparison. Subjects answered surveys evaluating alexithymia, anxiety, depression, and pain catastrophizing. Group data were compared using linear mixed effects and analysis of variance.
resultsStudy groups were similar by sex but not age. Significant group by pain condition interactions were observed in interoceptive brain regions during pain anticipation, and within perceptual brain regions during perceived pain. Higher activation within interoceptive brain regions during anticipated pain was observed in IBS compared with IBD and HC subjects. IBD patients demonstrated increased activation in perceptual brain regions during experienced pain as compared to IBS and HC.
conclusionsIBS and IBD AYA demonstrate altered neural processing of somatic pain compared with each other and with HC. Our results suggest that neuromodulatory interventions targeting interoceptive brain circuits in IBS and perceptual brain regions in IBD may be effective.
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