ReviewBurns & trauma2016
Skin tissue engineering advances in severe burns: review and therapeutic applications.
Review in Burns & trauma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 289 citations in OpenAlex.
- Hypoxia-preconditioned gingiva-derived mesenchymal stem cell-conditioned medium accelerates burn wound healing.Scientific reports · 2026Article
- RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies.Life (Basel, Switzerland) · 2026Review
- Engineering the Healing Process: Advanced In Vitro Wound Models and Technologies.Biomedicines · 2026Review
- Cell-Laden Supramolecular and Covalent Polymer Hydrogels for High-Shear Delivery: A Design of Experiments Approach.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- A Novel Sprayable Fibrinogen/Glycosaminoglycans/Collagen-Based Bioink for Skin Wound Healing Applied by a Handheld Dual-Head Airbrush.Advanced healthcare materials · 2026Article
- The Role of Biodegradable Temporizing Matrix in Hand Surgery for Paediatric Recessive Dystrophic Epidermolysis Bullosa.Journal of clinical medicine · 2026Article
- Natural Compound-Loaded PLGA Nanocarriers for Infected Wound Management: A Review.International journal of nanomedicine · 2026Review
- Utilization of a Multi-Tissue Extracellular Matrix in Complex Wound Care in Gaza: A Case Series.Antibiotics (Basel, Switzerland) · 2025Article
- Article
- Bioactive Supramolecular Polymers for Skin Regeneration Following Burn Injury.Biomacromolecules · 2025Article
- Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents.Nature communications · 2025Article
- Exploring the Rheological Properties of 3D Bioprinted Alginate-Based Hydrogels for Tissue Engineering.Biomimetics (Basel, Switzerland) · 2025Article
- Review of the 100 Most Cited Articles inEuropean burn journal · 2025Review
- From Data to Decisions: Leveraging Retrieval-Augmented Generation to Balance Citation Bias in Burn Management Literature.European burn journal · 2025Article
- The Role of Skin Substitutes in the Therapeutical Management of Burns Affecting Functional Areas.Medicina (Kaunas, Lithuania) · 2025Review
- SVF-gel application for the alleviation of full-thickness skin graft contraction: an experimental study in mice.Scientific reports · 2025Article
- Delivering living medicines with biomaterials.Nature reviews. Materials · 2025Article
- B cells recruitment promotes M2 macrophage polarization to inhibit inflammation during wound healing.Clinical and experimental immunology · 2025Article
- Expansion of Human Epidermal Keratinocytes in Co-culture with Human Feeder Cells.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Human urine-derived stem cells rescue cutaneous manifestation and suppress inflammation and fibrosisBurns & trauma · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes: a class of products that is still fraught with limitations for clinical use. Although the ability to grow autologous keratinocytes in-vitro from a small skin biopsy into sheets of stratified epithelium (within 3 to 4 weeks) helped alleviate the problem of insufficient donor site for extensive burn, many burn units still have to grapple with insufficient skin allografts which are used as intermediate wound coverage after burn excision. Alternatives offered by tissue-engineered skin dermal replacements to meet emergency demand have been used fairly successfully. Despite the availability of these commercial products, they all suffer from the same problems of extremely high cost, sub-normal skin microstructure and inconsistent engraftment, especially in full thickness burns. Clinical practice for severe burn treatment has since evolved to incorporate these tissue-engineered skin substitutes, usually as an adjunct to speed up epithelization for wound closure and/or to improve quality of life by improving the functional and cosmetic results long-term. This review seeks to bring the reader through the beginnings of skin tissue engineering, the utilization of some of the key products developed for the treatment of severe burns and the hope of harnessing stem cells to improve on current practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.