ArticleBurns & trauma2013
Honey exposure stimulates wound repair of human dermal fibroblasts.
Article in Burns & trauma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 69 citations in OpenAlex.
- Analytical Strategies for the Detection of Pesticides, Antibiotics, and Heavy Metals in Honey: Current Advances and Implications for Food Safety.Foods (Basel, Switzerland) · 2026Review
- The In Vitro Wound-Scratch Assay: Applications, Technical Advances, and Limitations in Wound Healing Research.International wound journal · 2026Review
- Botanical Origin-Dependent Phytochemical Profiles and Pharmaceutical Properties of Medical-Grade Honeys: Transdermal Delivery and Antibacterial Efficacy in a Wound Fluid Model.Molecules (Basel, Switzerland) · 2026Article
- Clinical and Postoperative Applications of Manuka Honey in Wound Healing: An Evidence-Based Review.International wound journal · 2026Review
- Honey and cancer: from traditional medicine to modern adjuvant therapy.Frontiers in oncology · 2026Review
- Biomaterials Based on Bee Products and Their Effectiveness in Soft Tissue Regeneration.Materials (Basel, Switzerland) · 2025Article
- Current State and Advances in Antimicrobial Strategies for Burn Wound Dressings: From Metal-Based Antimicrobials and Natural Bioactive Agents to Future Perspectives.International journal of molecular sciences · 2025Review
- Harnessing Manuka Honey: A Natural Remedy for Accelerated Burn Wound Healing in a Porcine Model.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Correlation between Honey Parameters and Wound Healing Properties: The Case of Piedmont (Italy) Samples.Current pharmaceutical biotechnology · 2025Article
- Anti-Inflammatory and Wound Healing Properties of Different Honey Varieties from Romania and Correlations to Their Composition.Life (Basel, Switzerland) · 2024Article
- The Potential of Fish Oil Components and Manuka Honey in Tackling Chronic Wound Treatment.Microorganisms · 2024Review
- Wound Repair and CaCells · 2024Review
- Medical Honey in Head and Neck Cancer.Cureus · 2024Review
- Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications.Polymers · 2023Review
- Antibacterial and Antibiofilm Effect of Unifloral Honeys against Bacteria Isolated from Chronic Wound Infections.Microorganisms · 2023Article
- Secretion of IL-6 by fibroblasts exposed to Australian honeys involves lipopolysaccharide and is independent of floral source.Scientific reports · 2022Article
- Advancements in Skin Delivery of Natural Bioactive Products for Wound Management: A Brief Review of Two Decades.Pharmaceutics · 2022Review
- Enhanced Healing Activity of Manuka Honey and Nitrofurazone Composite in Full-Thickness Burn Wounds in the Rabbit Model.Frontiers in veterinary science · 2022Article
- Article
- Honey in wound healing: An updated review.Open life sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Honey is widely used for treating burns, ulcers and wounds, but the mechanisms of action are poorly known and the product is mainly used as an antimicrobial. We have examined here the wound healing properties of honey on human fibroblasts, using an in vitro scratch wound healing model. Three kinds of widely used monofloral honeys were used, viz. acacia (Robinia pseudacacia), buckwheat (Fagopyrum sp.), and manuka (Leptospermum scoparium). Data displayed an increased wound healing activity in fibroblasts, but with different efficiency and mechanisms of action among honeys. The effects of acacia and buckwheat emerged in both scratch wound and chemotaxis assays, while the effect of manuka was significant but lower. The use of inhibitors indicated on the whole an essential role of cytosolic calcium, an important role of ERK and p38, and a secondary role of PI3K. Acacia and buckwheat, but not manuka, induced significant increases in the release of interleukin-4 (IL-4), IL-6, and IL-8, indicating a correlation between interleukin upregulation and wound closure efficiency. This is consistent with our previous findings suggesting a higher ability of acacia and buckwheat to activate keratinocyte reepithelialization, with respect to manuka honey. In conclusion, our data indicate that acacia and buckwheat honeys are particularly efficient in facilitating fibroblast wound closure activities, suggesting new therapeutic possibilities for this natural product.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.