ArticleWorld journal of clinical cases2016
Cronkhite-Canada syndrome polyps infiltrated with IgG4-positive plasma cells.
Article in World journal of clinical cases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Cronkhite-Canada syndrome: An elusive gastrointestinal disorder with multisystem involvement-pathogenesis, diagnosis, and therapeutic strategies.World journal of gastrointestinal pathophysiology · 2026Review
- IgG4-Related Kidney Disease With Pancreatic Mass and Protein-Losing Enteropathy: A Case Report.Kidney medicine · 2026Article
- Challenges and Opportunities in Cronkhite-Canada Syndrome Research: A Bibliometric Analysis Based on the Web of Science Core Collection.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Polyposis of gastrointestinal tract after COVID-19 mRNA vaccination: a report of two cases.Clinical endoscopy · 2024Article
- Cronkhite‒Canada syndrome as inflammatory hamartomatous polyposis: new evidence from whole transcriptome sequencing of colonic polyps.Orphanet journal of rare diseases · 2024Article
- Comprehensive treatment and a rare presentation of Cronkhite-Canada syndrome: Two case reports and review of literature.World journal of gastrointestinal surgery · 2023Article
- Exome analysis for Cronkhite-Canada syndrome: A case report.World journal of clinical cases · 2022Article
- Cronkhite-Canada Syndrome: A Case Report.JNMA; journal of the Nepal Medical Association · 2022Article
- Cronkhite-Canada syndrome: from clinical features to treatment.Gastroenterology report · 2020Review
- Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome.World journal of clinical cases · 2018Review
- Cronkhite-Canada syndrome: A case report.Oncology letters · 2018Article
- Cronkhite-Canada Syndrome: Sustained Clinical Response with Anti-TNF Therapy.Case reports in medicine · 2018Article
- Clinical and Endoscopic Response to Anti-Tumor Necrosis Factor-Alpha Antibody Therapy in a Patient With Cronkhite-Canada Syndrome.Journal of investigative medicine high impact case reportsArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cronkhite-Canada syndrome (CCS) is a rare but serious protein-losing enteropathy, but little is known about the mechanism. Further more, misdiagnosis is common due to non-familiarity of its clinical manifestation. A 40-year-old male patient was admitted to our hospital because of diarrhea and hypogeusia associated with weight loss for 4 mo. On physical examination, skin pigmentation, dystrophic nail changes and alopecia were noted. He had no alike family history. Laboratory results revealed low levels of serum albumin (30.1 g/L, range: 35.0-55.0 g/L), serum potassium (2.61 mmol/L, range: 3.5-5.5 mmol/L) and blood glucose (2.6 mmol/L, range: 3.9-6.1 mmol/L). The erythrocyte sedimentation rate was elevated to 17 mm/h (range: 0-15 mm/h). X-ray of chest and mandible was normal. The endoscopic examination showed multiple sessile polyps in the stomach, small bowel and colorectum. Histopathologic examination of biopsies obtained from those polyps showed hyperplastic change, cystic dilatation and distortion of glands with inflammatory infiltration, eosinophilic predominance and stromal edema. Immune staining for IgG4 plasma cells was positive in polyps of stomach and colon. The patient was diagnosed of CCS and treated with steroid, he had a good response to steroid. Both histologic findings and treatment response to steroid suggested an autoimmune mechanism underling CCS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.