ReviewThe world journal of men's health2016
Clinical Outcomes of Varicocele Repair in Infertile Men: A Review.
Review in The world journal of men's health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Adjuvant treatment with Wu-Zi-Yan-Zong formula for abnormal sperm parameters associated with male infertility: a meta-analysis of randomized controlled trials.Frontiers in pharmacology · 2025Pooled it
- Surgical or radiological treatment for varicoceles in subfertile men.The Cochrane database of systematic reviews · 2021Pooled it
- Effects of Varicocele Surgical Repair on Serum Hormone and Inhibin B Levels for Patients With Varicocele: A Systematic Review and Meta-Analysis.American journal of men's healthPooled it
- Progress of the pathogenesis in varicocele: a narrative review.The Canadian journal of urology · 2026Review
- Sperm DNA methylation landscape in infertile men with clinical varicocele: unravelling the treatment effect.Journal of endocrinological investigation · 2026Article
- Three-Dimensional Laparoscopic Varicocelectomy as the New Microsurgical Technique: Safety, Efficiency, and Outcomes.Cureus · 2025Article
- Molecular Remodeling of the Sperm Proteome Following Varicocele Sclero-Embolization: Implications for Semen Quality Improvement.Proteomes · 2025Article
- Article
- Involvement of autophagy in germ cells in an experimental model of varicocele in rats before and after varicocelectomy.Pediatric surgery international · 2024Article
- Beyond the Incision: A Comparative Study of Suprainguinal and Inguinal Varicocele Surgeries.Cureus · 2024Article
- Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study.International journal of fertility & sterility · 2024Article
- Case Report: Longitudinal follow-up and testicular sperm extraction in a patient with a pathogenicFrontiers in endocrinology · 2023Article
- The effects of varicocelectomy on the DNA fragmentation index and other sperm parameters: a meta-analysis.Basic and clinical andrology · 2020Review
- Protective effect of MOTILIPERM in varicocele-induced oxidative injury in rat testis by activating phosphorylated inositol requiring kinase 1α (p-IRE1α) and phosphorylated c-Jun N-terminal kinase (p-JNK) pathways.Pharmaceutical biology · 2018Article
- Effects of Varicocelectomy on Serum Testosterone Levels among Infertile Men with Varicocele.International journal of fertility & sterility · 2018Article
- Effect of Varicocelectomy on Serum FSH and LH Levels for Patients with Varicocele: a Systematic Review and Meta-analysis.The Indian journal of surgery · 2018Article
- Current Issues in Adolescent Varicocele: Pediatric Urological Perspectives.The world journal of men's health · 2018Review
- Long-term clinical outcomes of testicular sperm extraction and intracytoplasmic sperm injection for infertile men.Reproductive medicine and biology · 2018Article
- The Role of Varicocele in Male Factor Subfertility.Current urology reports · 2017Review
- The Dilemma of Adolescent Varicoceles: Do They Really Have to Be Repaired?Current urology reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Varicoceles are a major cause of impaired spermatogenesis and the most common correctable cause of male infertility. They are found in approximately 40% of men with primary infertility and 80% of men with secondary infertility, although they also occur in 12% of men with normal semen parameters. The presence of a varicocele does not always affect spermatogenesis, as it has been reported that only 20% of men with documented varicoceles suffer fertility problems. However, varicocele repair appears to have beneficial effects in men with impaired semen parameters and palpable varicoceles. Currently, the main procedures employed for varicocele repair are microsurgical subinguinal or inguinal varicocelectomy, laparoscopic varicocelectomy, and radiological percutaneous embolization. Microsurgical varicocelectomy appears to be the optimal treatment in most cases, whereas the other procedures are useful only in specific cases. After treatment, it typically takes 3 to 6 months for patients' semen parameters to improve; thus, other therapies, including assisted reproductive technology, should be considered if infertility persists after this interval, especially in older couples. Controversies still remain regarding how varicoceles in certain subgroups, such as adolescents or men with azoospermia, should be treated. Due to their relatively high prevalence rate among the general population, varicoceles can occur concomitantly with other conditions that cause impaired spermatogenesis. Further studies are necessary in order to identify the patients who are most likely to benefit from treatment. In this review, we sought to summarize the issues currently associated with varicocele treatment in infertile men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.