Evidence map›Paper›PMID 27574551›Full record

ReviewWorld journal of gastrointestinal oncology2016

Regulation of CTNNB1 signaling in gastric cancer and stem cells.

Shihori Tanabe, Kazuhiko Aoyagi, Hiroshi Yokozaki, Hiroki Sasaki

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastrointestinal oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  8. Effects of hormones on intestinal stem cells.Stem cell research & therapy · 2023
    Review
  9. Article
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  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Shihori TanabeShihori Tanabe, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, Tokyo 158-8501, Japan.
Kazuhiko AoyagiShihori Tanabe, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, Tokyo 158-8501, Japan.
Hiroshi YokozakiShihori Tanabe, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, Tokyo 158-8501, Japan.
Hiroki SasakiShihori Tanabe, Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Science, Tokyo 158-8501, Japan.
National Institute of Infectious Diseases · JPCreative Research Enterprises (United States) · USKobe University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent research has shown that the alteration of combinations in gene expression contributes to cellular phenotypic changes. Previously, it has been demonstrated that the combination of cadherin 1 and cadherin 2 expression can identify the diffuse-type and intestinal-type gastric cancers. Although the diffuse-type gastric cancer has been resistant to treatment, the precise mechanism and phenotypic involvement has not been revealed. It may be possible that stem cells transform into gastric cancer cells, possibly through the involvement of a molecule alteration and signaling mechanism. In this review article, we focus on the role of catenin beta 1 (CTNNB1 or β-catenin) and describe the regulation of CTNNB1 signaling in gastric cancer and stem cells.

Indexed as

CTNNB1 signalingEpithelial-mesenchymal transitionGastric cancerStem cellβ-catenin

Identifiers

PMID27574551
PMCPMC4980649
OpenAlexW2516471757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.