ArticleFrontiers in genetics2016
Associations between Polygenic Risk for Psychiatric Disorders and Substance Involvement.
Article in Frontiers in genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Schizophrenia Polygenic Risk and Experiences of Childhood Adversity: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2022Pooled it
- A Mapping Literature Review of Medical Cannabis Clinical Outcomes and Quality of Evidence in Approved Conditions in the USA from 2016 to 2019.Medical cannabis and cannabinoids · 2021Pooled it
- Use of polygenic risk scores of nicotine metabolism in predicting smoking behaviors.Pharmacogenomics · 2018Pooled it
- Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.JAMA psychiatry · 2017Pooled it
- Prevalence and risk factors of depression, anxiety, and stress among secondary school students in Abha city, Saudi Arabia.Frontiers in psychiatry · 2026Article
- Shared genetic effects among schizophrenia, substance use disorder, and hippocampal volume in a multiplex extended pedigree sample.Schizophrenia research · 2026Article
- Naturalistic Psychedelic Use and Psychotic Symptoms: A Cross-Sectional Study of Individuals with a Personal or Family History of Psychotic or Bipolar Disorders.Psychedelic medicine (New Rochelle, N.Y.) · 2025Article
- Cannabis and psychopathology: 2024 Snapshot of a meandering journey.Indian journal of psychiatry · 2025Review
- Article
- Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.Psychological medicine · 2024Article
- Association between ADHD symptoms and illicit stimulants use following 1 year among French university students of the i-Share cohort.Social psychiatry and psychiatric epidemiology · 2024Article
- Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders.Psychiatry research · 2024Article
- Specificity of Psychiatric Polygenic Risk Scores and Their Effects on Associated Risk Phenotypes.Biological psychiatry global open science · 2023Article
- Lifetime prevalence and treatment of mental disorders in Saudi youth and adolescents.Scientific reports · 2023Article
- Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.Psychological medicine · 2023Article
- The Medication Use Issues and Challenges of Mental Illness Exacerbation in Patients with Schizophrenia: A Qualitative Study in Thailand.Patient preference and adherence · 2023Article
- Investigation of Association of Rare, Functional Genetic Variants With Heavy Drinking and Problem Drinking in Exome Sequenced UK Biobank Participants.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Article
- Associations between cannabis use, cannabis use disorder, and mood disorders: longitudinal, genetic, and neurocognitive evidence.Psychopharmacology · 2022Review
- Attention deficit hyperactivity disorder symptoms and cannabis use after one year among students of the i-Share cohort.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Examining pathways between genetic liability for schizophrenia and patterns of tobacco and cannabis use in adolescence.Psychological medicine · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Despite evidence of substantial comorbidity between psychiatric disorders and substance involvement, the extent to which common genetic factors contribute to their co-occurrence remains understudied. In the current study, we tested for associations between polygenic risk for psychiatric disorders and substance involvement (i.e., ranging from ever-use to severe dependence) among 2573 non-Hispanic European-American participants from the Study of Addiction: Genetics and Environment. Polygenic risk scores (PRS) for cross-disorder psychopathology (CROSS) were generated based on the Psychiatric Genomics Consortium's Cross-Disorder meta-analysis and then tested for associations with a factor representing general liability to alcohol, cannabis, cocaine, nicotine, and opioid involvement (GENSUB). Follow-up analyses evaluated specific associations between each of the five psychiatric disorders which comprised CROSS-attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (AUT), bipolar disorder (BIP), major depressive disorder (MDD), and schizophrenia (SCZ)-and involvement with each component substance included in GENSUB. CROSS PRS explained 1.10% of variance in GENSUB in our sample (p < 0.001). After correction for multiple testing in our follow-up analyses of polygenic risk for each individual disorder predicting involvement with each component substance, associations remained between: (A) MDD PRS and non-problem cannabis use, (B) MDD PRS and severe cocaine dependence, (C) SCZ PRS and non-problem cannabis use and severe cannabis dependence, and (D) SCZ PRS and severe cocaine dependence. These results suggest that shared covariance from common genetic variation contributes to psychiatric and substance involvement comorbidity.
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