ArticleOperative techniques in orthopaedics2016
Application of Tendon Stem/Progenitor Cells and Platelet-Rich Plasma to Treat Tendon Injuries.
Article in Operative techniques in orthopaedics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Platelet-rich plasma as a treatment for plantar fasciitis: A meta-analysis of randomized controlled trials.Medicine · 2017Pooled it
- A systematic review and meta-analysis of platelet-rich plasma versus corticosteroid injections for plantar fasciopathy.International orthopaedics · 2017Pooled it
- [Ultrasound-Guided PRP for Tendinopathy: a Practical, Multimodal Framework from Biology to Rehabilitation].Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 2026Review
- Stem cell approaches for tendon repair: delusion or insight.The Journal of physiology · 2025Review
- Mesenchymal Stem Cells in Veterinary Medicine-Still Untapped Potential.Animals : an open access journal from MDPI · 2025Review
- Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies.Frontiers in bioengineering and biotechnology · 2023Review
- Global research trends on platelet-rich plasma for tendon and ligament injuries from the past two decades: A bibliometric and visualized study.Frontiers in surgery · 2023Article
- The Functions and Mechanisms of Basic Fibroblast Growth Factor in Tendon Repair.Frontiers in physiology · 2022Review
- Comparison of midterm results of Platelet Rich Plasma (PRP) versus Steroid for plantar fasciitis: A randomized control trial of 118 patients.Journal of clinical orthopaedics and trauma · 2021Article
- Innovative Strategies in Tendon Tissue Engineering.Pharmaceutics · 2021Review
- An antibacterial and injectable calcium phosphate scaffold delivering human periodontal ligament stem cells for bone tissue engineering.RSC advances · 2020Article
- Tensile strength, growth factor content and proliferation activities for two platelet concentrates of platelet-rich fibrin and concentrated growth factor.Journal of dental sciences · 2020Article
- LncRNA TUG1 promoted osteogenic differentiation through promoting bFGF ubiquitination.In vitro cellular & developmental biology. Animal · 2020Article
- Biologics and stem cell-based therapies for rotator cuff repair.Annals of the New York Academy of Sciences · 2019Review
- Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon.Journal of orthopaedic surgery and research · 2018Article
- Evaluation of subcutaneous infiltration of autologous platelet-rich plasma on skin-wound healing in dogs.Bioscience reports · 2017Article
- Advances of stem cell based-therapeutic approaches for tendon repair.Journal of orthopaedic translation · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tendon injuries like tendinopathy are a serious healthcare problem in the United States. However, current treatments for tendon injuries are largely palliative. Biologics treatments, including tendon stem/progenitor cells (TSCs) and platelet rich plasma (PRP) hold great potential to effectively treat tendon injuries. TSCs are tendon specific stem cells and have the ability to differentiate into tenocytes, the resident tendon cells responsible for tendon homeostasis and tendon repair in case of an injury. TSCs can also self-renew and thus can replenish the tendon with tendon cells (TSCs and tenocytes) to maintain a healthy tendon. The action of PRP can be complementary; PRP can augment and accelerate tendon healing by supplying abundant growth factors contained in platelets, and fibrin matrix, which functions as a natural conducive scaffold to facilitate tissue healing. This article provides a summary of the findings in recent basic and clinical studies on the applications of TSCs and PRP to the treatment of tendon injuries. It also outlines the challenges facing their applications in clinical settings. In particular, the controversy surrounding the efficacy of PRP treatment for tendon injuries are analyzed and solutions are suggested.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.