ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead.Neuroscience and biobehavioral reviews · 2019Pooled it
- The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions.Nature neuroscience · 2026Article
- BOLD response delays represent local cortical processing.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Network mechanisms of ongoing brain activity's influence on conscious visual perception.Nature communications · 2024Article
- WidefieldNeurophotonics · 2024Article
- Tissue Oxygen Depth Explorer: an interactive database for microscopic oxygen imaging data.Frontiers in neuroinformatics · 2023Article
- Baseline oxygen consumption decreases with cortical depth.PLoS biology · 2022Article
- Hybrid fiber optic-fMRI for multimodal cell-specific recording and manipulation of neural activity in rodents.Neurophotonics · 2022Review
- Toward an integrative neurovascular framework for studying brain networks.Neurophotonics · 2022Article
- Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Neurophotonic tools for microscopic measurements and manipulation: status report.Neurophotonics · 2022Article
- A Suite of Neurophotonic Tools to Underpin the Contribution of Internal Brain States in fMRI.Current opinion in biomedical engineering · 2021Article
- Opposed hemodynamic responses following increased excitation and parvalbumin-based inhibition.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Simultaneous cortex-wide fluorescence CaNature methods · 2020Article
- Article
- Spatial and temporal patterns of nitric oxide diffusion and degradation drive emergent cerebrovascular dynamics.PLoS computational biology · 2020Article
- Functional ultrasound imaging of deep visual cortex in awake nonhuman primates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Intracranial pressure elevation alters CSF clearance pathways.Fluids and barriers of the CNS · 2020Article
- The potential for gas-free measurements of absolute oxygen metabolism during both baseline and activation states in the human brain.NeuroImage · 2020Article
- Vascular and neural basis of the BOLD signal.Current opinion in neurobiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 7 institutions in 3 countries.
Funding
Abstract
The computational properties of the human brain arise from an intricate interplay between billions of neurons connected in complex networks. However, our ability to study these networks in healthy human brain is limited by the necessity to use non-invasive technologies. This is in contrast to animal models where a rich, detailed view of cellular-level brain function with cell-type-specific molecular identity has become available due to recent advances in microscopic optical imaging and genetics. Thus, a central challenge facing neuroscience today is leveraging these mechanistic insights from animal studies to accurately draw physiological inferences from non-invasive signals in humans. On the essential path towards this goal is the development of a detailed 'bottom-up' forward model bridging neuronal activity at the level of cell-type-specific populations to non-invasive imaging signals. The general idea is that specific neuronal cell types have identifiable signatures in the way they drive changes in cerebral blood flow, cerebral metabolic rate of O2 (measurable with quantitative functional Magnetic Resonance Imaging), and electrical currents/potentials (measurable with magneto/electroencephalography). This forward model would then provide the 'ground truth' for the development of new tools for tackling the inverse problem-estimation of neuronal activity from multimodal non-invasive imaging data.This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.