ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2016
Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed.
- Treatment-related Cognitive Impairment, Neurovascular Coupling, and Iron Levels in Women with Ovarian Cancer.medRxiv : the preprint server for health sciences · 2026Article
- A hypoxia-sensitive medullary nucleus modulates cerebral blood flow via a disynaptic pathway to cortex.bioRxiv : the preprint server for biology · 2026Article
- Nitric oxide is not responsible for initial sensory-induced neurovascular coupling response in the barrel cortex of lightly anesthetized mice.Neurophotonics · 2025Article
- SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling.Acta physiologica (Oxford, England) · 2025Article
- Article
- Correlation of zero echo time functional MRI with neuronal activity in rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- (Re)building the nervous system: A review of neuron-glia interactions from development to disease.Journal of neurochemistry · 2025Review
- Cerebral blood flow patterns induced by photoactivation based on laser speckle contrast imaging.Biomedical optics express · 2024Article
- Neocortical cholinergic pathology after neonatal brain injury is increased by Alzheimer's disease-related genes in mice.Neurobiology of disease · 2024Article
- Serotonergic regulation of cortical neurovascular coupling and hemodynamics upon awakening from sleep in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Cellular and molecular mechanisms of the blood-brain barrier dysfunction in neurodegenerative diseases.Fluids and barriers of the CNS · 2024Review
- Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation.Scientific reports · 2024Article
- An interaction graph approach to gain new insights into mechanisms that modulate cerebrovascular tone.Communications biology · 2024Review
- Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling.Nature neuroscience · 2024Article
- Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19.Brain communications · 2024Review
- Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation.Research square · 2023Article
- Cognition is entangled with metabolism: relevance for resting-state EEG-fMRI.Frontiers in human neuroscience · 2023Article
- Improving the validity of neuroimaging decoding tests of invariant and configural neural representation.PLoS computational biology · 2023Article
- Article
- Spectral fiber photometry derives hemoglobin concentration changes for accurate measurement of fluorescent sensor activity.Cell reports methods · 2022Article
4 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
Brain imaging techniques that use vascular signals to map changes in neuronal activity, such as blood oxygenation level-dependent functional magnetic resonance imaging, rely on the spatial and temporal coupling between changes in neurophysiology and haemodynamics, known as 'neurovascular coupling (NVC)'. Accordingly, NVC responses, mapped by changes in brain haemodynamics, have been validated for different stimuli under physiological conditions. In the cerebral cortex, the networks of excitatory pyramidal cells and inhibitory interneurons generating the changes in neural activity and the key mediators that signal to the vascular unit have been identified for some incoming afferent pathways. The neural circuits recruited by whisker glutamatergic-, basal forebrain cholinergic- or locus coeruleus noradrenergic pathway stimulation were found to be highly specific and discriminative, particularly when comparing the two modulatory systems to the sensory response. However, it is largely unknown whether or not NVC is still reliable when brain states are altered or in disease conditions. This lack of knowledge is surprising since brain imaging is broadly used in humans and, ultimately, in conditions that deviate from baseline brain function. Using the whisker-to-barrel pathway as a model of NVC, we can interrogate the reliability of NVC under enhanced cholinergic or noradrenergic modulation of cortical circuits that alters brain states.This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'.
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