Trial reportCancer prevention research (Philadelphia, Pa.)2016
Higher Glucose and Insulin Levels Are Associated with Risk of Liver Cancer and Chronic Liver Disease Mortality among Men without a History of Diabetes.
Trial report in Cancer prevention research (Philadelphia, Pa.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- A burden of proof study of the effects of exposure to high fasting plasma glucose on the risk of seven types of cancer.Scientific reports · 2025Pooled it
- Systematic Review with Meta-Analysis: Low-Level Alcohol Consumption and the Risk of Liver Cancer.Gut and liver · 2020Pooled it
- Blood glucose concentration and risk of liver cancer: systematic review and meta-analysis of prospective studies.Oncotarget · 2017Pooled it
- ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis.The Journal of clinical investigation · 2025Trial
- Establishment of insulin resistance-related ten-gene signature in endometrial cancer and identification of ACTL8 as a prognostic and immunological biomarker.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Artificially Sweetened and Sugar-Sweetened Beverage Intake and Risk of Liver Cancer.JAMA network open · 2026Article
- Health effects associated with alcohol consumption: a Burden of Proof study.Nature health · 2026Article
- Assessment of Adipokine and Inflammation Biomarkers with Cancer Risk among Chinese Men: A Prospective Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Influence of healthy lifestyle on the incidence and survival of cancer and its comorbidities: evidence from a longitudinal cohort study.Journal of translational medicine · 2025Article
- Young Adults and Alcohol-Associated Liver Cancer: Incidence and Death from 2000 to 2021.Cancers · 2025Article
- The Interlinking Metabolic Association between Type 2 Diabetes Mellitus and Cancer: Molecular Mechanisms and Therapeutic Insights.Diagnostics (Basel, Switzerland) · 2024Review
- Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2024Review
- Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity.Obesity (Silver Spring, Md.) · 2024Article
- T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis.Frontiers in oncology · 2024Article
- METS-IR and all-cause mortality in Korean over 60 years old: Korean genome and epidemiology study-health examinees (KoGES-HEXA) cohorts.Frontiers in endocrinology · 2024Article
- Dietary inflammatory and insulinemic potential, risk of hepatocellular carcinoma, and chronic liver disease mortality.JNCI cancer spectrum · 2023Article
- Associations between serum glucose, insulin, insulin resistance and the risk of incident primary liver cancer or chronic liver disease mortality: a nested case-control study.British journal of cancer · 2023Article
- A prospective investigation of serum bile acids with risk of liver cancer, fatal liver disease, and biliary tract cancer.Hepatology communications · 2022Article
- Insulin-Lowering Diets in Metastatic Cancer.Nutrients · 2022Review
- Fasting Insulin and Risk of Overall and 14 Site-Specific Cancers: Evidence From Genetic Data.Frontiers in oncology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Insulin resistance likely increases the risk of chronic liver disease (CLD) and liver cancer, but long-term prospective studies with measured fasting glucose and insulin are lacking. We evaluated the associations of prediagnostic fasting glucose, insulin, and the homeostasis model assessment of insulin resistance (HOMA-IR) with liver cancer and CLD mortality in a prospective study of Finnish male smokers with extended follow-up time (≤22 years) and information on known risk factors using data from 138 incident primary liver cancer cases, 216 CLD deaths, and 681 matched controls. Fasting glucose and insulin were measured in baseline serum. We used unconditional logistic regression to estimate ORs and 95% confidence intervals adjusted for age, alcohol, education, smoking, body mass index, and hepatitis B and C viral status. Among those without self-reported diabetes, glucose was positively associated with liver cancer [quartile 3 vs. quartile 1 (Q3/Q1): OR = 1.88; 1.03-3.49; Q4/Q1: OR = 2.40; 1.33-4.35; P
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.