Trial reportScientific reports2016
The critical role of phase difference in gamma oscillation within the temporoparietal network for binding visual working memory.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is transcranial alternating current stimulation effective for improving working memory? A three-level meta-analysis.Psychonomic bulletin & review · 2025Pooled it
- Triangular Wave tACS Improves Working Memory Performance by Enhancing Brain Activity in the Early Stage of Encoding.Neuroscience bulletin · 2025Trial
- Neural mechanisms of feature binding in working memory.Communications biology · 2026Article
- Dual-site theta stimulation modulates connectivity, but not sequence memory in older adults.Brain communications · 2026Article
- Review
- Network Segregation and Integration Changes in Healthy Aging: Evidence From EEG Subbands During the Visual Short-Term Memory Binding Task.The European journal of neuroscience · 2025Article
- Preclinical insights into gamma-tACS: foundations for clinical translation in neurodegenerative diseases.Frontiers in neuroscience · 2025Review
- Neural oscillations induced by gamma sensory entrainment in cognitive biotype of depression.Frontiers in psychiatry · 2025Article
- Sensory stimulation enhances visual working memory capacity.Communications psychology · 2024Article
- Enhancing visual working memory in schizophrenia: effects of frontoparietal theta tACS in low-performing patients.Schizophrenia (Heidelberg, Germany) · 2024Article
- Theta-gamma-coupling as predictor of working memory performance in young and elderly healthy people.Molecular brain · 2024Article
- Improving working memory by electrical stimulation and cross-frequency coupling.Molecular brain · 2024Article
- No effects of the theta-frequency transcranial electrical stimulation for recall, attention control, and relation integration in working memory.Frontiers in human neuroscience · 2024Article
- Insights into conscious cognitive information processing.Frontiers in behavioral neuroscience · 2024Article
- A Review on Motor Imagery with Transcranial Alternating Current Stimulation: Bridging Motor and Cognitive Welfare for Patient Rehabilitation.Brain sciences · 2023Review
- Transcranial alternating current stimulation over multiple brain areas with non-zero phase delays other than 180 degrees modulates visuospatial working memory performance.Scientific reports · 2023Article
- The role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex.Scientific reports · 2023Article
- Neurocognitive, physiological, and biophysical effects of transcranial alternating current stimulation.Trends in cognitive sciences · 2023Review
- Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead.Frontiers in integrative neuroscience · 2023Review
- 10 Minutes Frontal 40 Hz tACS-Effects on Working Memory Tested by Luck-Vogel Task.Behavioral sciences (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How does the brain enable us to remember two or more object representations in visual working memory (VWM) without confusing them? This "gluing" process, or feature binding, refers to the ability to join certain features together while keeping them segregated from others. Recent neuroimaging research has reported higher BOLD response in the left temporal and parietal cortex during a binding-VWM task. However, less is known about how the two regions work in synchrony to support such process. In this study, we applied transcranial alternating current stimulation (tACS) over the left temporal and parietal cortex in gamma and theta frequency, with a phase difference of either 0° (in-phase) or 180° (anti-phase) to account for the different ways through which neural synchronization may occur. We found no facilitatory or inhibitory effect from sham, theta, and in-phase gamma stimulation. Importantly, there was an enhancement effect from anti-phase gamma tACS that was binding-specific, and such effect was only apparent in low-performing individuals who had room for improvement. Together, these results demonstrate that binding-VWM is supported by a temporally-precise oscillatory mechanism within the gamma frequency range, and that the advantageous 180°-apart phase relationship also implies a possible temporal driver-to-receiver time-lag between the temporal and parietal cortex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.