ArticlePediatric blood & cancer2017
Prospective study of neuropathic pain after definitive surgery for extremity osteosarcoma in a pediatric population.
Article in Pediatric blood & cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Effect of Different Anesthesia Methods on Emergence Agitation and Related Complications in Postoperative Patients with Osteosarcoma.Journal of healthcare engineering · 2021Trial
- Prospective randomized trial of interventions for vincristine-related neuropathic pain.Pediatric blood & cancer · 2020Trial
- Outcomes Following Targeted Muscle Reinnervation in Pediatric Amputations: A Systematic Review.Plastic and reconstructive surgery. Global open · 2026Article
- Article
- Review
- A Narrative Review of Pain in Pediatric Oncology: The Opioid Option.Paediatric drugs · 2024Review
- The Pharmacological Treatment of Neuropathic Pain in Children.Current neuropharmacology · 2024Review
- Perioperative Indications for Gabapentinoids in Pediatrics: A Narrative Review.Paediatric drugs · 2023Review
- LncRNA PCED1B-AS1 knockdown inhibits osteosarcoma via methylation-mediated miR-10a downregulation.Journal of orthopaedic surgery and research · 2022Article
- Evaluation of neuropathic pain with diverse pathophysiologies in childhood cancers.Northern clinics of Istanbul · 2022Article
- Psychosocial Factors and Psychological Interventions: Implications for Chronic Post-Surgical Pain in Pediatric Patients with Osteosarcoma.Journal of clinical psychology in medical settings · 2021Article
- Alterations in Muscle Architecture: A Review of the Relevance to Individuals After Limb Salvage Surgery for Bone Sarcoma.Frontiers in pediatrics · 2020Article
- Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm.Paediatric drugs · 2019Article
- Role of Amputation in Improving Mobility, Pain Outcomes, and Emotional and Psychological Well-Being in Children With Metastatic Osteosarcoma.The American journal of hospice & palliative care · 2019Article
- Cyclic Guanosine Monophosphate (cGMP)-Dependent Protein Kinase II Blocks Epidermal Growth Factor (EGF)/Epidermal Growth Factor Receptor (EGFR)-Induced Biological Effects on Osteosarcoma Cells.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- A prospective observational study to assess the incidence of neuropathic pain after bone and soft tissue cancer surgery.Journal of anaesthesiology, clinical pharmacologyArticle
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8 authors.
Funding
Abstract
backgroundNeuropathic pain (NP) after definitive surgery for extremity osteosarcoma (OS) has not been previously characterized. This study prospectively investigates the incidence, duration, and treatment of NP in limb sparing surgery and amputation groups. PROCEDURE: In patients treated for OS on a chemotherapy and definitive surgery (limb sparing vs. amputation) protocol (OS08), we prospectively collected the following data: (i) demographical data (age, sex, race); (ii) NP time of onset and duration; and (iii) dose (starting, maximum) and duration of gabapentin, amitriptyline, and methadone treatment.
resultsThirty-seven patients underwent 38 definitive surgeries: limb sparing (26, 68.4%) or amputations (12, 31.6%). Localization included lower extremity (30, 81%), upper extremity (6, 16%), or pelvis (1, 3%). Thirty patients (81%) developed NP and 26 of them required NP-specific medications (87.7%). The mean [standard deviation (SD)] duration of NP was 6.5 weeks (7.2) (median 4.4, range 0.3-29.9). All 26 patients (27 surgeries) treated with NP medications received gabapentin, either as single therapy (65.4%) (17 patients, 18 surgeries), dual therapy with gabapentin and amitriptyline (five patients), or triple therapy with gabapentin, amitriptyline, and methadone (four patients). The mean starting (maximum) doses of gabapentin, amitriptyline, and methadone (mg/kg/day) were 20.2 (43.8), 0.5 (0.7), and 0.3 (0.3), respectively. The incidence and duration of NP, duration of treatment, and NP-specific dose regimens were similar in the limb sparing and the amputation groups.
conclusionsNP after definitive surgery for OS is frequently encountered, can persist for a significant time, and NP outcomes are similar in limb sparing and amputation groups.
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