ArticleThe American journal of tropical medicine and hygiene2016
Cognitive Performance and Iron Status are Negatively Associated with Hookworm Infection in Cambodian Schoolchildren.
Article in The American journal of tropical medicine and hygiene, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Parasitic Infections and Associated Cognitive Outcome Among School-Aged Children in Africa: A Systematic Review.Brain and behavior · 2026Pooled it
- Hookworm infection and its determinants among schoolchildren in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- The extent, nature, and pathogenic consequences of helminth polyparasitism in humans: A meta-analysis.PLoS neglected tropical diseases · 2019Pooled it
- Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects.Molecules (Basel, Switzerland) · 2021Trial
- The effect of cumulative soil-transmitted helminth infections over time on child development: a 4-year longitudinal cohort study in preschool children using Bayesian methods to adjust for exposure misclassification.International journal of epidemiology · 2018Trial
- Article
- A systematic review and meta-analysis of the association between neglected tropical diseases and malnutrition: more research needed on diseases other than intestinal parasites, leishmaniasis and leprosy.Access microbiology · 2024Article
- Soil-transmitted helminth infection in pregnancy and long-term child neurocognitive and behavioral development: A prospective mother-child cohort in Benin.PLoS neglected tropical diseases · 2021Article
- Diagnostic Techniques for Soil-Transmitted Helminths - Recent Advances.Research and reports in tropical medicine · 2021Review
- The Heterogeneity, Origins, and Impact of Migratory iILC2 Cells in Anti-helminth Immunity.Frontiers in immunology · 2020Review
- Cognitive and Microbiome Impacts of Experimental Ancylostoma ceylanicum Hookworm Infections in Hamsters.Scientific reports · 2019Article
- Porcine cysticercosis (Taenia solium and Taenia asiatica): mapping occurrence and areas potentially at risk in East and Southeast Asia.Parasites & vectors · 2018Article
- A longitudinal cohort study of soil-transmitted helminth infections during the second year of life and associations with reduced long-term cognitive and verbal abilities.PLoS neglected tropical diseases · 2018Article
- Strongyloides stercoralis and hookworm co-infection: spatial distribution and determinants in Preah Vihear Province, Cambodia.Parasites & vectors · 2018Article
- Albendazole and ivermectin for the control of soil-transmitted helminths in an area with high prevalence of Strongyloides stercoralis and hookworm in northwestern Argentina: A community-based pragmatic study.PLoS neglected tropical diseases · 2017Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soil-transmitted helminth (STH) infection has been associated with lower cognitive performance of schoolchildren. To identify pathways through which STH infection might affect school performance, baseline data from a large rice-fortification trial in Cambodian schoolchildren were used to investigate associations between STH infection, micronutrient status, anemia, and cognitive performance. Complete data on anthropometry, cognitive performance, and micronutrient status were available for 1,760 schoolchildren, 6-16 years of age. STH infection was identified using Kato-Katz, whereas cognitive performance was assessed using Raven's Colored Progressive Matrices (RCPM), block design, and picture completion. STH infection was found in 18% of the children; almost exclusively hookwork infection. After adjusting for age and gender, raw cognitive test scores were significantly lower in hookworm-infected children (-0.65; -0.78; -2.03 points for picture completion, RCPM, and block design, respectively; P < 0.05 for all). Hookworm infection was associated with iron status (total body iron), but not with vitamin A and zinc status, nor with inflammation or anthropometry. Body iron was negatively associated with increased intensity of hookworm infection (R = 0.22, P < 0.001). Hookworm infection in Cambodian schoolchildren was associated with lower cognitive performance, an effect most likely mediated through lower body iron. Interventions that are more effective against hookworm infection are needed to contribute to better health and improvement of cognitive performance.
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