ArticleScientific reports2016
Dynamic transition of neuronal firing induced by abnormal astrocytic glutamate oscillation.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 57 citations in OpenAlex.
- ACognitive neurodynamics · 2024Article
- The role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence.Cognitive neurodynamics · 2024Article
- Astrocytic modulation of neuronal signalling.Frontiers in network physiology · 2023Review
- Astrocytic modulation on neuronal electric mode selection induced by magnetic field effect.Cognitive neurodynamics · 2022Article
- Dysregulation of Ambient Glutamate and Glutamate Receptors in Epilepsy: An Astrocytic Perspective.Frontiers in neurology · 2021Review
- A Computational Study of Astrocytic GABA Release at the Glutamatergic Synapse: EAAT-2 and GAT-3 Coupled Dynamics.Frontiers in cellular neuroscience · 2021Article
- A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation.Computational and mathematical methods in medicine · 2020Article
- Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation.Neural plasticity · 2020Article
- Dynamic Transitions in Neuronal Network Firing Sustained by Abnormal Astrocyte Feedback.Neural plasticity · 2020Article
- Bifurcation analysis and diverse firing activities of a modified excitable neuron model.Cognitive neurodynamics · 2019Article
- A computational study of astrocytic glutamate influence on post-synaptic neuronal excitability.PLoS computational biology · 2018Article
- Computational Models for Calcium-Mediated Astrocyte Functions.Frontiers in computational neuroscience · 2018Review
- Minimum Winfree loop determines self-sustained oscillations in excitable Erdös-Rényi random networks.Scientific reports · 2017Article
- Action potential initiation in a two-compartment model of pyramidal neuron mediated by dendritic CaScientific reports · 2017Article
- Combined Effects of Feedforward Inhibition and Excitation in Thalamocortical Circuit on the Transitions of Epileptic Seizures.Frontiers in computational neuroscience · 2017Article
- Metabolic Energy of Action Potentials Modulated by Spike Frequency Adaptation.Frontiers in neuroscience · 2016Article
- Assessing the Effects of Opioids on Pathological Memory by a Computational Model.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gliotransmitter glutamate released from astrocytes can modulate neuronal firing by activating neuronal N-methyl-D-aspartic acid (NMDA) receptors. This enables astrocytic glutamate(AG) to be involved in neuronal physiological and pathological functions. Based on empirical results and classical neuron-glial "tripartite synapse" model, we propose a practical model to describe extracellular AG oscillation, in which the fluctuation of AG depends on the threshold of calcium concentration, and the effect of AG degradation is considered as well. We predict the seizure-like discharges under the dysfunction of AG degradation duration. Consistent with our prediction, the suppression of AG uptake by astrocytic transporters, which operates by modulating the AG degradation process, can account for the emergence of epilepsy.
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