ArticleEuropean journal of nutrition2018
Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion.
Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Relationship between maternal caffeine and coffee intake and pregnancy loss: A grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of observational studies.Frontiers in nutrition · 2022Pooled it
- The relationship between first trimester maternal diet and early pregnancy loss: a retrospective case-control study.BMC pregnancy and childbirth · 2026Article
- Maternal Caffeine Consumption and Pregnancy Outcomes.Advances in experimental medicine and biology · 2026Review
- Mechanisms and Pathophysiological Significance of Insulin Resistance in Offspring With Intrauterine Growth Restriction Mediated by Hepatic GR/miR-1224 Programming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The Fetal Effect of Maternal Caffeine Consumption During Pregnancy-A Review.Biomedicines · 2025Review
- Preconception sleep duration, non-daytime work schedules, and incidence of spontaneous abortion: a prospective cohort study.Human reproduction (Oxford, England) · 2024Article
- Prevalence and consumption pattern of kolanut among pregnant women in Ibadan metropolis.Scientific reports · 2023Article
- Beyond body mass index: a synthesis of lifestyle factors that may influence in vitro fertilisation outcomes.British journal of midwifery · 2023Article
- Pre-pregnancy Diet to Maternal and Child Health Outcome: A Scoping Review of Current Evidence.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2023Article
- Development of a nutrition screening tool to identify need for dietetic intervention in female infertility.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023Review
- Caffeine use during pregnancy: prevalence of use and newborn consequences in a cohort of French pregnant women.European archives of psychiatry and clinical neuroscience · 2021Article
- Risk score to stratify miscarriage risk levels in preconception women.Scientific reports · 2021Article
- Maternal caffeine consumption and pregnancy outcomes: a narrative review with implications for advice to mothers and mothers-to-be.BMJ evidence-based medicine · 2021Review
- Environmental & occupational exposure & female reproductive dysfunction.The Indian journal of medical research · 2019Review
- Biases Inherent in Studies of Coffee Consumption in Early Pregnancy and the Risks of Subsequent Events.Nutrients · 2018Review
- Diet and fertility: a review.American journal of obstetrics and gynecology · 2018Review
- Association between preconception maternal beverage intake and in vitro fertilization outcomes.Fertility and sterility · 2017Article
- The Safety of Ingested Caffeine: A Comprehensive Review.Frontiers in psychiatry · 2017Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo investigate the relation between pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion (SAB).
methodsOur prospective cohort study included 15,590 pregnancies from 11,072 women with no history of SAB in the Nurses' Health Study II (1991-2009). Beverage intake was assessed every 4 years using a validated questionnaire. Pregnancies were self-reported with case pregnancies lost spontaneously at <20 weeks gestation. Multivariable log-binomial regression models with generalized estimating equations were used to estimate the relative risks (RRs) and 95 % confidence intervals (CIs).
resultsThere was a positive linear trend across categories of pre-pregnancy caffeine intake and risk of SAB such that women consuming >400 mg/day had 1.11 (95 % CI 0.98, 1.25) times the risk of SAB compared to women consuming <50 mg/day (p trend = 0.05). Total coffee intake had a positive, linear association with SAB. Compared to women with no pre-pregnancy coffee intake, women consuming ≥4 servings/day had a 20 % (6, 36 %) increased risk of SAB (p trend = 0.01). There was no difference in the association between caffeinated and decaffeinated coffee and risk of SAB. Pre-pregnancy intake of caffeinated tea, caffeinated soda, and decaffeinated soda had no association with SAB.
conclusionsPre-pregnancy coffee consumption at levels ≥4 servings/day is associated with increased risk of SAB, particularly at weeks 8-19.
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Registered trials
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