ArticleActa neurologica Scandinavica2017
White matter hyperintensity lesion burden is associated with the infarct volume and 90-day outcome in small subcortical infarcts.
Article in Acta neurologica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Optical coherence tomography angiography in cerebral small vessel disease: a review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Review
- The impact of cerebral vessels morphological alteration and white matter hyperintensities burden on the one-year risk of ischemic stroke recurrence.BMC medical imaging · 2025Article
- Clinical and imaging risk factors for early neurological deterioration and long-term neurological disability in patients with single subcortical small infarction.BMC neurology · 2025Article
- White matter hyperintensity burden and infarct volume predict functional outcomes in anterior choroidal artery stroke: a multimodal MRI study.Frontiers in neuroscience · 2025Article
- Impact of White Matter Hyperintensity Volume on Prognosis After Mechanical Thrombectomy in Ischemic Stroke Patients.Stroke (Hoboken, N.J.) · 2024Article
- Impact of white matter hyperintensity volumes estimated by automated methods using deep learning on stroke outcomes in small vessel occlusion stroke.Frontiers in aging neuroscience · 2024Article
- Impact of High-Intensity Statin on Early Neurologic Deterioration in Patients with Single Small Subcortical Infarction.Journal of clinical medicine · 2023Article
- Clinical features and FLAIR radiomics nomogram for predicting functional outcomes after thrombolysis in ischaemic stroke.Frontiers in neuroscience · 2023Article
- The Clinical Utility of Leukoaraiosis as a Prognostic Indicator in Ischemic Stroke Patients.Neurology international · 2022Review
- The protective impact of education on brain structure and function in Alzheimer's disease.BMC neurology · 2021Article
- Hemispheric cerebral blood flow predicts outcome in acute small subcortical infarcts.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Lacunar Stroke Lesion Extent and Location and White Matter Hyperintensities Evolution 1 Year Post-lacunar Stroke.Frontiers in neurology · 2021Article
- Prognostic Structural Neural Markers of MRI in Response to Mechanical Thrombectomy for Basilar Artery Occlusion.Frontiers in neurology · 2021Article
- Within-lesion heterogeneity of subcortical DWI lesion evolution, and stroke outcome: A voxel-based analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Observational
- Patterns of brain structural alteration in COPD with different levels of pulmonary function impairment and its association with cognitive deficits.BMC pulmonary medicine · 2019Article
- Cognitive Decline in Asymptomatic Middle Cerebral Artery Stenosis Patients with Moderate and Poor Collaterals: A 2-Year Follow-Up Study.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Pre-existing White Matter Hyperintensity Lesion Burden and Diagnostic Certainty of Transient Ischemic Attack.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Article
- Total Small Vessel Disease Burden Predicts Functional Outcome in Patients With Acute Ischemic Stroke.Frontiers in neurology · 2019Article
- Brain Structural Correlates of Odor Identification in Mild Cognitive Impairment and Alzheimer's Disease Revealed by Magnetic Resonance Imaging and a Chinese Olfactory Identification Test.Frontiers in neuroscience · 2019Article
- Relationship between White Matter Hyperintensities and Hematoma Volume in Patients with Intracerebral Hematoma.Aging and disease · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesSmall subcortical infarcts (SSI) frequently coexist with brain white matter hyperintensity (WMH) lesions. We sought to determine whether preexisting WMH burden relates to SSI volume, SSI etiology, and 90-day functional outcome. MATERIALS AND
methodsWe retrospectively studied 80 consecutive patients with acute SSI. Infarct volume was determined on diffusion weighted imaging, and WMH burden was graded on fluid-attenuated inversion recovery sequences according to the Fazekas scale. SSI etiology was categorized as small vessel disease (SVD) vs non-SVD related. Multivariable linear and logistic regression models were constructed to determine whether WMH burden was independently associated with the SSI volume and a poor 90-day outcome (modified Rankin scale [mRS] score >2), respectively.
resultsIn unadjusted analyses, patients with non-SVD-related SSI were older (P=.002) and more frequently had multiple infarcts (P<.001) than patients with SVD-related SSI. In the fully adjusted model, WMH severity (Coefficient 0.07; 95%-CI 0.029-0.117; P=.002) but not SSI etiology (P>.1) was independently associated with the SSI volume. On multivariable logistic regression, worse WMH (OR 2.28; 95%-CI 1.04-4.99; P=.040), SSI etiology (OR 9.20; 95%-CI 1.04-81.39; P=.046), preadmission mRS (OR 8.96; 95%-CI 2.65-30.27; P<.001), and SSI volume (OR 1.98; 95%-CI 1.14-3.44; P=.016) were associated with a poor 90-day outcome.
conclusionsGreater WMH burden is independently associated with a larger SSI volume and a worse 90-day outcome.
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