ReviewAngewandte Chemie (International ed. in English)2016
Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?
Review in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Regio- and Stereocontrolled-Synthesis of a Heterocycle Fragment Collection Using Palladium Catalyzed C-H Arylation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Article
- Modular, automated synthesis of spirocyclic tetrahydronaphthyridines from primary alkylamines.Communications chemistry · 2023Article
- Regiodivergent synthesis of sulfone-tethered lactam-lactones bearing four contiguous stereocenters.RSC advances · 2023Article
- Pyridylic anions are soft nucleophiles in the palladium-catalyzed C(spChemical science · 2020Article
- Is it time for biocatalysis in fragment-based drug discovery?Chemical science · 2020Review
- Transition-metal and oxidant-free approach for the synthesis of diverse N-heterocycles by TMSCl activation of isocyanides.RSC advances · 2020Article
- Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor.Angewandte Chemie (International ed. in English) · 2020Article
- Identification of selective protein-protein interaction inhibitors using efficientChemical science · 2019Article
- Access to 3D Alicyclic Amine-Containing Fragments through Transannular C-H Arylation.Synlett : accounts and rapid communications in synthetic organic chemistry · 2019Article
- Automated and Accelerated Synthesis of Indole Derivatives on a Nano-Scale.Green chemistry : an international journal and green chemistry resource : GC · 2019Article
- Expanding the medicinal chemistry synthetic toolbox.Nature reviews. Drug discovery · 2018Review
- Cyclometallated ruthenium catalyst enables late-stage directed arylation of pharmaceuticals.Nature chemistry · 2018Article
- Organic synthesis provides opportunities to transform drug discovery.Nature chemistry · 2018Review
- Divergent Synthesis of Cyclopropane-Containing Lead-Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl Sulfide.European journal of organic chemistry · 2017Article
- Bioactive Natural Product and Superacid Chemistry for Lead Compound Identification: A Case Study of Selective hCA III and L-Type CaMolecules (Basel, Switzerland) · 2017Review
- Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents.ACS central science · 2017Article
- Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?Angewandte Chemie (International ed. in English) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As our understanding of the impact of specific molecular properties on applications in discovery-based disciplines improves, the extent to which published synthetic methods meet (or do not meet) desirable criteria is ever clearer. Herein, we show how the application of simple (and in many cases freely available) computational tools can be used to develop a semiquantitative understanding of the potential of new methods to support molecular discovery. This analysis can, among other things, inform the design of improved substrate scoping studies; direct the prioritization of specific exemplar structures for synthesis; and substantiate claims of potential future applications for new methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.