Observational studyEuropean journal of pediatrics2016
Relationship of clinical symptoms with biomarkers of inflammation in pediatric inflammatory bowel disease.
Observational study in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Inflammatory Markers Stratify Surgical Outcomes in Pediatric Airway Reconstruction.The Laryngoscope · 2026Article
- Fatigue in pediatric inflammatory bowel disease: Explained by transdiagnostic and disease-focused factors.Journal of pediatric gastroenterology and nutrition · 2026Article
- Integrated multi-omics of feces, plasma and urine can describe and differentiate pediatric active Crohn's Disease from remission.Communications medicine · 2025Article
- Neutrophil-to-Lymphocyte Ratio at Diagnosis Predicts Colonoscopic Activity in Pediatric Inflammatory Bowel Diseases.Clinical and translational gastroenterology · 2025Article
- Correlation Between Serum and Fecal Biomarkers and Patient-Reported Outcomes in Patients with Crohn's Disease and Ulcerative Colitis.Digestive diseases and sciences · 2024Article
- Dietary Therapy to Improve Nutrition and Gut Health in Paediatric Crohn's Disease; A Feasibility Study.Nutrients · 2022Article
- Evaluation of Fecal Calprotectin, Serum C-Reactive Protein, Erythrocyte Sedimentation Rate, Seromucoid and Procalcitonin in the Diagnostics and Monitoring of Crohn's Disease in Children.Journal of clinical medicine · 2022Article
- Serum inflammatory markers in the diagnosis and assessment of Crohn's disease activity.Archives of medical science : AMS · 2021Article
- MRI-Based Radiomic Signature Identifying Secondary Loss of Response to Infliximab in Crohn's Disease.Frontiers in nutrition · 2021Article
- Usefulness of Testing for Fecal Calprotectin in Pediatric Gastroenterology Clinical Practice.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Review
- Expert opinion for use of faecal calprotectin in diagnosis and monitoring of inflammatory bowel disease in daily clinical practice.United European gastroenterology journal · 2018Review
- Association of fecal calprotectin concentrations with disease severity, response to treatment, and other biomarkers in dogs with chronic inflammatory enteropathies.Journal of veterinary internal medicine · 2018Article
- Observational
- Inflammatory bowel diseases: a burden in pediatrics: Case series and a review of the literature.Medicine · 2017Article
- Assessing the correlation between fecal calprotectin, blood markers and disease activity in pediatric inflammatory bowel disease.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledIn adult inflammatory bowel disease (IBD) patients, there is a strong discrepancy between symptoms and biomarkers of inflammation. Data on pediatric IBD patients are conflicting. Therefore, we aimed to investigate the relationship between clinical symptoms and biomarkers of inflammation in pediatric IBD. Patients aged <18 years with previously diagnosed Crohn's disease (CD) or ulcerative colitis (UC) were included. Clinical disease activity was determined using the abbreviated Pediatric CD Activity Index (aPCDAI) or Pediatric UC Activity Index (PUCAI). Biochemical disease activity was assessed using fecal calprotectin (FC) and C-reactive protein (CRP). In total, 127 patients (62 male; median age 14.9 years) were included (82 CD, 45 UC). FC correlated weakly with total aPCDAI score (r s = 0.32; 95 % CI 0.12-0.51; p = 0.003) and total PUCAI score (r s = 0.36; 95 % CI 0.07-0.62; p = 0.015). Only aPCDAI components abdominal examination and perirectal disease and PUCAI component activity level had a significant correlation with levels of FC. CRP correlated weakly with total aPCDAI score (r s = 0.28; 95 % CI 0.05-0.46; p = 0.012) and aPCDAI components abdominal examination and activity level. No significant correlation was observed between CRP and total PUCAI score (r s = 0.01; 95 % CI -0.34-0.29; p = 0.961) or individual PUCAI components.
conclusionThere is a strong discrepancy between clinical symptoms and biomarkers of inflammation in children with IBD. WHAT IS KNOWN: • A substantial proportion of asymptomatic pediatric inflammatory bowel disease (IBD) patients have elevated biomarkers of inflammation. • There is a strong discrepancy between symptoms and biomarkers of inflammation in adults with IBD. What is New: • Clinical symptoms are only weakly associated with levels of fecal calprotectin and serum C-reactive protein in children and adolescents with previously diagnosed IBD. • Similarly to adult IBD patients, there is a strong discrepancy between clinical symptoms and biomarkers of inflammation in children with IBD.
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