Evidence map›Paper›PMID 27573249›Full record

ArticleJournal of proteome research2016

Highlights of the Biology and Disease-driven Human Proteome Project, 2015-2016.

Jennifer E Van Eyk, Fernando J Corrales, Ruedi Aebersold, Ferdinando Cerciello, Eric W Deutsch, Paola Roncada, Jean-Charles Sanchez, Tadashi Yamamoto, Pengyuan Yang, Hui Zhang and 1 more

Abstract read
In one paragraph

Article in Journal of proteome research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. The SysteMHC Atlas project.Nucleic acids research · 2018
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jennifer E Van EykAdvanced Clinical BioSystems Research Institute, Department of Medicine, Cedars-Sinai Medical Centre , Los Angeles, California 90038, United States.
Fernando J CorralesDepartment of Hepatology, Proteomics Laboratory, CIMA, University of Navarra; Ciberhed; PRB2, ProteoRed-ISCIII, 31008 Pamplona, Spain.
Ruedi AebersoldDepartment of Biology, Institute of Molecular Systems Biology, ETH Zürich , 8093 Zürich, Switzerland.
Ferdinando CercielloDepartment of Biology, Institute of Molecular Systems Biology, ETH Zürich , 8093 Zürich, Switzerland.
Eric W DeutschInstitute for Systems Biology , Seattle, Washington 98109, United States.
Paola RoncadaIstituto Sperimentale Italiano L. Spallanzani , 20133 Milano, Italy.
Jean-Charles SanchezCentre Medicale Universitaire , Human Protein Sciences Department, CH-1211 Geneva, Switzerland.
Tadashi YamamotoNiigata University , Department of Structural Pathology, Institute of Nephrology, Medical and Dental School, Asachimachi-dori Niigata 951-8510, Japan.
Pengyuan YangFudan University , Department of Chemistry, Shanghai 200433, P.R. China.
Hui ZhangJohns Hopkins University , Department of Pathology, Baltimore, Maryland 21287, United States.
Gilbert S OmennCenter for Computational Medicine and Bioinformatics, University of Michigan , Ann Arbor, Michigan 48109, United States.

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
NIEHS NIH HHS P30 ES017885
6 · The paper itself

Abstract

The Biology and Disease-driven Human Proteome Project (B/D-HPP) is aimed at supporting and enhancing the broad use of state-of-the-art proteomic methods to characterize and quantify proteins for in-depth understanding of the molecular mechanisms of biological processes and human disease. Based on a foundation of the pre-existing HUPO initiatives begun in 2002, the B/D-HPP is designed to provide standardized methods and resources for mass spectrometry and specific protein affinity reagents and facilitate accessibility of these resources to the broader life sciences research and clinical communities. Currently there are 22 B/D-HPP initiatives and 3 closely related HPP resource pillars. The B/D-HPP groups are working to define sets of protein targets that are highly relevant to each particular field to deliver relevant assays for the measurement of these selected targets and to disseminate and make publicly accessible the information and tools generated. Major developments are the 2016 publications of the Human SRM Atlas and of "popular protein sets" for six organ systems. Here we present the current activities and plans of the BD-HPP initiatives as highlighted in numerous B/D-HPP workshops at the 14th annual HUPO 2015 World Congress of Proteomics in Vancouver, Canada.

Indexed as

ProteomeBiomedical ResearchComputational BiologyDatabases, ProteinDiseaseHuman Genome ProjectHumansInformation ServicesMass SpectrometryProteomicsProteomeB/D-HPPBiology and Disease-driven Human Proteome Projectmass spectrometryMSselected reaction monitoring−MSSRM−MS

Identifiers

PMID27573249
PMCPMC5129618

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.