ArticleJournal of medical ethics2018
The Ebola clinical trials: a precedent for research ethics in disasters.
Article in Journal of medical ethics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Implementation of accelerated research: strategies for implementation as applied in a phase 1 Ad26.ZEBOV, MVA-BN-Filo two-dose Ebola vaccine clinical trial in Uganda.Global health action · 2020Trial
- Understanding Ethical Concerns Involving Vulnerable Human Participant Populations in Medical Research: Mixed-Method Analysis of Liberian Ebola Survivors' Experiences in PREVAIL I-VII.Healthcare (Basel, Switzerland) · 2024Article
- Research ethics during infectious disease outbreaks: A survey of African research stakeholders using the Ebola virus disease outbreak as a case.Journal of public health in Africa · 2023Article
- Identifying the scope of ethical challenges caused by the Ebola epidemic 2014-2016 in West Africa: a qualitative study.Philosophy, ethics, and humanities in medicine : PEHM · 2022Article
- Implementing an outpatient clinical trial on COVID-19 treatment in an emergency epidemic context: a mixed methods study among operational and research stakeholders within the Coverage trial, Bordeaux (France).Archives of public health = Archives belges de sante publique · 2022Article
- Pharmaceutical messianism and the COVID-19 pandemic.Social science & medicine (1982) · 2022Article
- Conditions of Global Health Crisis Decision-Making-An Ethical Analysis.Journal of bioethical inquiry · 2021Article
- Ethical Dimensions of Public Health Actions and Policies With Special Focus on COVID-19.Frontiers in public health · 2021Review
- Ethics of emerging infectious disease outbreak responses: Using Ebola virus disease as a case study of limited resource allocation.PloS one · 2021Article
- SARS-CoV-2, ACE2, and Hydroxychloroquine: Cardiovascular Complications, Therapeutics, and Clinical Readouts in the Current Settings.Pathogens (Basel, Switzerland) · 2020Review
- Challenges and strategies to research ethics in conducting COVID-19 research.Journal of evidence-based medicine · 2020Article
- COVID-19, Chloroquine Repurposing, and Cardiac Safety Concern: Chirality Might Help.Molecules (Basel, Switzerland) · 2020Article
- The Plasma Mobile, 'A gift from heaven': The impact of health technology transfer on trial perceptions and expectations during the Ebola-Tx Trial, Conakry.PLoS neglected tropical diseases · 2020Article
- Prioritising gender, equity, and human rights in a GRADE-based framework to inform future research on self care for sexual and reproductive health and rights.BMJ global health · 2020Article
- A systematic literature review of the ethics of conducting research in the humanitarian setting.Conflict and health · 2020Article
- Review
- A New Method for Ethical and Efficient Evidence Generation for Off-Label Medication Use in Oncology (A Case Study in Glioblastoma).Frontiers in pharmacology · 2019Article
- EBOVAC-Salone: Lessons learned from implementing an Ebola vaccine trial in an Ebola-affected country.Clinical trials (London, England) · 2018Article
- Clinicians' attitude towards a placebo-controlled randomised clinical trial investigating the effect of neuraminidase inhibitors in adults hospitalised with influenza.BMC health services research · 2018Article
- Towards a genomics-informed, real-time, global pathogen surveillance system.Nature reviews. Genetics · 2018Review
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Funding
No grant is acknowledged in the PubMed record.
Abstract
The West African Ebola epidemic has set in motion a collective endeavour to conduct accelerated clinical trials, testing unproven but potentially lifesaving interventions in the course of a major public health crisis. This unprecedented effort was supported by the recommendations of an ad hoc ethics panel convened in August 2014 by the WHO. By considering why and on what conditions the exceptional circumstances of the Ebola epidemic justified the use of unproven interventions, the panel's recommendations have challenged conventional thinking about therapeutic development and clinical research ethics. At the same time, unanswered ethical questions have emerged, in particular: (i) the specification of exceptional circumstances, (ii) the specification of unproven interventions, (iii) the goals of interventional research in terms of individual versus collective interests, (iv) the place of adaptive trial designs and (v) the exact meaning of compassionate use with unapproved interventions. Examination of these questions, in parallel with empirical data from research sites, will help build pragmatic foundations for disaster research ethics. Furthermore, the Ebola clinical trials signal an evolution in the current paradigms of therapeutic research, beyond the case of epidemic emergencies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.