ArticleScientific reports2016
Prevalence and Abundance of Florfenicol and Linezolid Resistance Genes in Soils Adjacent to Swine Feedlots.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 104 citations in OpenAlex.
- Effects of florfenicol on linezolid resistance in Enterococcus faecium from waterfowl farms.Poultry science · 2026Article
- Genetic diversity and mobile genetic element associated multidrug resistance in Salmonella enterica from broiler chickens in Egypt.Scientific reports · 2026Article
- Global dissemination of optrA-mediated linezolid resistance in enterococci.The Journal of antimicrobial chemotherapy · 2026Article
- Global distribution and genomic characteristics of linezolid resistance gene-positiveFrontiers in microbiology · 2026Article
- Review
- Study on the Plateau Adaptive Synergistic Mechanism of Rumen Microbiome-Metabolome-Resistome in Tibetan Sheep.Microorganisms · 2025Article
- Article
- IS6 family insertion sequences promote optrA dissemination between plasmids varying in transfer abilities.Applied microbiology and biotechnology · 2024Article
- Risk Factor Analysis for Occurrence of Linezolid-Resistant Bacteria in the Digestive and Respiratory Tract of Food-Producing Animals in Belgium: A Pilot Study.Antibiotics (Basel, Switzerland) · 2024Article
- Impact of Soil Fertilization with Pig Slurry on Antibiotic Residues and Resistance Genes: A Longitudinal Study.Antibiotics (Basel, Switzerland) · 2024Article
- Phylogeny of Transferable Oxazolidinone Resistance Genes and Homologs.Antibiotics (Basel, Switzerland) · 2024Article
- Mapping the widespread distribution and transmission dynamics of linezolid resistance in humans, animals, and the environment.Microbiome · 2024Article
- Impact of florfenicol dosing regimen on the phenotypic and genotypic resistance of enteric bacteria in steers.Scientific reports · 2024Article
- Detection of florfenicol resistance in opportunisticFrontiers in microbiology · 2024Article
- Presence ofMicrobiology (Reading, England) · 2022Article
- Molecular characterization of florfenicol and oxazolidinone resistance inFrontiers in microbiology · 2022Article
- Characterization and comparative genomics analysis of RepA_N multi-resistance plasmids carryingFrontiers in microbiology · 2022Article
- Florfenicol and oxazolidone resistance status in livestock farms revealed by short- and long-read metagenomic sequencing.Frontiers in microbiology · 2022Article
- Metagenomics analysis revealed the distinctive ruminal microbiome and resistive profiles in dairy buffaloes.Animal microbiome · 2021Article
- Characterization of florfenicol resistance genes in the coagulase-negative Staphylococcus (CoNS) isolates and genomic features of a multidrug-resistant Staphylococcus lentus strain H29.Antimicrobial resistance and infection control · 2021Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Florfenicol is extensively used in livestock to prevent or cure bacterial infections. However, it is not known whether the administration of florfenicol has resulted in the emergence and dissemination of florfenicol resistance genes (FRGs, including fexA, fexB, cfr, optrA, floR, and pexA) in microbial populations in surrounding farm environments. Here we collected soil samples for the detection of FRGs and the residue of florfenicol from six swine farms with the record of florfenicol usage. Quantitative polymerase chain reaction and metagenomic sequencing revealed a significantly higher relative abundance of FRGs in the soils adjacent to the three swine farms where florfenicol was heavily used compared with the other sites. Meanwhile, the detectable levels of florfenicol were also identified in soils from two of these three farms using ultra-performance liquid chromatography tandem mass spectrometry. It appears that amount of florfenicol used on swine farms and the spreading of soils with swine waste could promote the prevalence and abundance of FRGs, including the linezolid resistance genes cfr and optrA, in adjacent soils, and agricultural application of swine manure with florfenicol may have caused a residual level of florfenicol in the soils.
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