Different Genotype of rs3130932 Single Nucleotide Polymorphism Between Gastric Cancer Patients and Normal Subjects.

Zahra Shahhoseini, Fereshteh Jeivad, Nematollah Ahangar, Saeid Abediankenari

Abstract read

In one paragraph

Article in Journal of gastrointestinal cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review.Clinical and experimental gastroenterology · 2020
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5 · Who and what money

Authors and funding

4 authors.

Zahra ShahhoseiniGastrointestinal Cancer Research Center, Mazandaran University of Medical Science, Sari, Iran.

Fereshteh JeivadDepartment of Toxicology & Pharmacology, Tehran University of Medical Science, Tehran, Iran.

Nematollah AhangarGastrointestinal Cancer Research Center, Mazandaran University of Medical Science, Sari, Iran.

Saeid AbediankenariImmunogenetics Research Center, Mazandaran University of Medical Science, Sari, Iran. abedianks@alumnus.tums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOctamer binding transcription factor B gene (OCT4) is responsible for development and self-renewal maintenance of embryonic stem cells. The rs3130932 single nucleotide polymorphism (SNP) may play a role in tumor genesis. Because of high prevalence of gastric cancer in north of Iran, this study was investigated role of rs3130932 polymorphism and stomach cancer.

methodsBlood samples were collected from 100 informed gastric cancer patients and 100 age and sex-matched healthy individuals, and were genotyped for the presence of rs3130932G allele by ssp PCR.

resultsThe mean age of participant (n = 200) was 67.83 ± 10.878 years. In genotyping and allelic analysis, TG genotype increased 66.147 times more likely to develop stomach cancer than the TT genotype, and disease risk increases 140.496 times more in GG genotype in comparison with TT genotype.

conclusionThis study clearly emphasis on different genetic profile in this population and show that the rs3130932G allele and odds of gastric cancer are related to each other in northern of Iran.

Indexed as

AgedCase-Control StudiesFemaleGenotypeHumansMalePolymorphism, Single NucleotideRisk FactorsStomach NeoplasmsGastric cancerOCT4 geneSingle nucleotide polymorphism

Identifiers

PMID27573011

DOI10.1007/s12029-016-9869-6

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