ArticleAge (Dordrecht, Netherlands)2016
Interspecific correlation between red blood cell mitochondrial ROS production, cardiolipin content and longevity in birds.
Article in Age (Dordrecht, Netherlands), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Article
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- From wetlands to landfills: white stork (Arhiv za higijenu rada i toksikologiju · 2025Review
- Mitochondrial function is enhanced by thyroid hormones during zebra finch development.Royal Society open science · 2024Article
- Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution.Genome biology and evolution · 2023Article
- Dietary Soy Saponin Improves Antioxidant and Immune Function of Layer Hens.The journal of poultry science · 2022Article
- Experimental demonstration of prenatal programming of mitochondrial aerobic metabolism lasting until adulthood.Proceedings. Biological sciences · 2022Article
- The influence of phylogeny and life history on telomere lengths and telomere rate of change among bird species: A meta-analysis.Ecology and evolution · 2021Review
- New Perspectives on Avian Models for Studies of Basic Aging Processes.Biomedicines · 2021Review
- Article
- Redox-regulation and life-history trade-offs: scavenging mitochondrial ROS improves growth in a wild bird.Scientific reports · 2019Article
- Longevity and life history coevolve with oxidative stress in birds.Functional ecology · 2019Article
- Oxidative Stress and Advanced Lipoxidation and Glycation End Products (ALEs and AGEs) in Aging and Age-Related Diseases.Oxidative medicine and cellular longevity · 2019Review
- Platelet mitochondrial cytochrome c oxidase subunit I variants with benzene poisoning.Journal of thoracic disease · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial respiration releases reactive oxygen species (ROS) as by-products that can damage the soma and may in turn accelerate ageing. Hence, according to "the oxidative stress theory of ageing", longer-lived organisms may have evolved mechanisms that improve mitochondrial function, reduce ROS production and/or increase cell resistance to oxidative damage. Cardiolipin, an important mitochondrial inner-membrane phospholipid, has these properties by binding and stabilizing mitochondrial inner-membrane proteins. Here, we investigated whether ROS production, cardiolipin content and cell membrane resistance to oxidative attack in freshly collected red blood cells (RBCs) are associated with longevity (range 5-35 years) in 21 bird species belonging to seven Orders. After controlling for phylogeny, body size and oxygen consumption, variation in maximum longevity was significantly explained by mitochondrial ROS production and cardiolipin content, but not by membrane resistance to oxidative attack. RBCs of longer-lived species produced less ROS and contained more cardiolipin than RBCs of shorter-lived species did. These results support the oxidative stress theory of ageing and shed light on mitochondrial cardiolipin as an important factor linking ROS production to longevity.
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