Evidence map›Paper›PMID 27572644›Full record

ArticleNature microbiology2016

Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype.

Leopoldo N Segal, Jose C Clemente, Jun-Chieh J Tsay, Sergei B Koralov, Brian C Keller, Benjamin G Wu, Yonghua Li, Nan Shen, Elodie Ghedin, Alison Morris and 10 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 426 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
426citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04700579 recruitingnot on this mapstarted 2021, after this paper: background citation

Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis

Typeobservational_patient_registrySponsorUniversity of StellenboschRan2021 to 2027Enrolled150ConditionsTB - Tuberculosis, HIV/AIDS
NCT05223114 completednot on this mapstarted 2022, after this paper: background citation

Airway Microbiome and Th17-mediated Inflammation in COPD Among HIV-infected Individuals in a Rural Ugandan Cohort

TypeobservationalSponsorMakerere UniversityRan2022 to 2023Enrolled160ConditionsCOPD, HIV Infections, Respiratory DiseaseArmsNot applicable (N/A)
3 · Its place in the literature

Who cites it

426 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  11. Myeloid cell reprogramming drives enhanced defense againstProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  13. Article
  14. Journal of bacteriology · 2026
    Review
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  20. Article

366 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Leopoldo N SegalDivision of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.
Jose C ClementeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.ORCID http://orcid.org/0000-0002-3970-9856
Jun-Chieh J TsayDivision of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.ORCID http://orcid.org/0000-0002-2282-2510
Sergei B KoralovDepartment of Pathology, New York University School of Medicine, New York, New York, USA.
Brian C KellerDivision of Pulmonary and Critical Care Medicine, The Ohio State University, Columbus, Ohio, USA.
Benjamin G WuDivision of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.
Yonghua LiDivision of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.
Nan ShenDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
Elodie GhedinDepartment of Biology, Center for Genomics &Systems Biology, College of Global Public Health, New York University, New York, New York, USA.
Alison MorrisDivision of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pennsylvania, USA.
Phillip DiazDivision of Pulmonary and Critical Care Medicine, The Ohio State University, Columbus, Ohio, USA.
Laurence HuangDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
William R WikoffDepartment of Molecular and Cellular Biology &Genome Center, University of California, Davis, California, USA.
Carles UbedaCenter for Public Health Research, FISABIO, Valencia, Spain.
Alejandro ArtachoCenter for Public Health Research, FISABIO, Valencia, Spain.
William N RomDivision of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.
Daniel H StermanDivision of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.
Ronald G CollmanDepartment of Medicine and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Martin J BlaserDepartment of Medicine, New York University School of Medicine, New York, New York, USA.
Michael D WeidenDivision of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, USA.

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
NATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2M
University of Pittsburgh Multicenter AIDS Cohort Study (MACS)U01AI035041 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MARTINSON, JEREMY JAMES, RINALDO, CHARLES R · 1993 to 2018
$71.4M
MULTICENTER AIDS COHORT STUDYU01AI035039 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WOLINSKY, STEVEN M · 1993 to 2018
$66.4M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Multicenter Aids Cohort Study- Part B (Baltimore Site)U01AI035042 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BROWN, TODD T, MARGOLICK, JOSEPH B. · 1993 to 2018
$61.5M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR000038NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1 TR001445NCI NIH HHS U01 CA086137NCRR NIH HHS M01 RR000722NHLBI NIH HHS K24 HL087713NHLBI NIH HHS K24 HL123342NHLBI NIH HHS R01 HL090339NHLBI NIH HHS R01 HL113252NHLBI NIH HHS R01 HL125816NHLBI NIH HHS U01 HL098957NHLBI NIH HHS U01 HL098962NIAID NIH HHS K23 AI102970NIAID NIH HHS K24 AI080298NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI035039NIAID NIH HHS U01 AI035040NIAID NIH HHS U01 AI035041NIAID NIH HHS U01 AI035042NIAID NIH HHS U01 AI035043NIAID NIH HHS U01 AI037613NIAID NIH HHS U01 AI037984NIAID NIH HHS U01 AI042590NIAID NIH HHS U01 AI103408NIAID NIH HHS U01 AI111598NIAID NIH HHS UM1 AI035043NIAMS NIH HHS UH2 AR057506NICHD NIH HHS U01 HD032632NIDDK NIH HHS R01 DK090989
6 · The paper itself

Abstract

Microaspiration is a common phenomenon in healthy subjects, but its frequency is increased in chronic inflammatory airway diseases, and its role in inflammatory and immune phenotypes is unclear. We have previously demonstrated that acellular bronchoalveolar lavage samples from half of the healthy people examined are enriched with oral taxa (here called pneumotypeSPT) and this finding is associated with increased numbers of lymphocytes and neutrophils in bronchoalveolar lavage. Here, we have characterized the inflammatory phenotype using a multi-omic approach. By evaluating both upper airway and acellular bronchoalveolar lavage samples from 49 subjects from three cohorts without known pulmonary disease, we observed that pneumotypeSPT was associated with a distinct metabolic profile, enhanced expression of inflammatory cytokines, a pro-inflammatory phenotype characterized by elevated Th-17 lymphocytes and, conversely, a blunted alveolar macrophage TLR4 response. The cellular immune responses observed in the lower airways of humans with pneumotypeSPT indicate a role for the aspiration-derived microbiota in regulating the basal inflammatory status at the pulmonary mucosal surface.

Indexed as

MicrobiotaBronchoalveolar Lavage FluidHumansPneumoniaRespiratory AspirationTh17 Cells

Identifiers

PMID27572644
PMCPMC5010013

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.