ArticleeLife2016
Functional integration of a serotonergic neuron in the Drosophila antennal lobe.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Connectivity of serotonin neurons reveals a constrained inhibitory subnetwork within the olfactory system.Journal of neurophysiology · 2026Article
- Oxygen-dependent regulation of serotonin receptoriScience · 2025Article
- Differential modulation of feedforward inhibition reflects topographic organization in the olfactory system.Nature communications · 2025Article
- Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning.PLoS biology · 2025Article
- Differential dopaminergic modulation of the antennal lobe of Drosophila melanogaster.Communications biology · 2025Article
- Ectopic sodium channel expression decreases excitability of Drosophila Kenyon cells.The Journal of physiology · 2025Article
- Serotonin selectively modulates visual responses of object motion detectors inJournal of neurophysiology · 2025Article
- Gustatory receptors interact with the serotonin pathway to regulate silkmoth stereotyped courtship behavior.BMC biology · 2025Article
- Serotonin selectively modulates visual responses of object motion detectors inbioRxiv : the preprint server for biology · 2025Article
- Serotonin acts through multiple cellular targets during an olfactory critical period.iScience · 2024Article
- Experience-dependent serotonergic signaling in glia regulates targeted synapse elimination.PLoS biology · 2024Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Decoding bee cleptoparasitism through comparative transcriptomics of Coelioxoides waltheriae and its host Tetrapedia diversipes.Scientific reports · 2024Article
- Serotonin acts through multiple cellular targets during an olfactory critical period.bioRxiv : the preprint server for biology · 2024Article
- Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter.Translational psychiatry · 2023Article
- Article
- Transcriptional changes in specific subsets of Drosophila neurons following inhibition of the serotonin transporter.Research square · 2023Article
- Anatomic and neurochemical analysis of the palpal olfactory system in the red flour beetleFrontiers in cellular neuroscience · 2023Article
- Serotonin/GABA receptors modulate odor input to olfactory receptor neuron in locusts.Frontiers in cellular neuroscience · 2023Article
- Identification and Pharmacological Characterization of Two Serotonin Type 7 Receptor Isoforms fromInternational journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Serotonin plays a critical role in regulating many behaviors that rely on olfaction and recently there has been great effort in determining how this molecule functions in vivo. However, it remains unknown how serotonergic neurons that innervate the first olfactory relay respond to odor stimulation and how they integrate synaptically into local circuits. We examined the sole pair of serotonergic neurons that innervates the Drosophila antennal lobe (the first olfactory relay) to characterize their physiology, connectivity, and contribution to pheromone processing. We report that nearly all odors inhibit these cells, likely through connections made reciprocally within the antennal lobe. Pharmacological and immunohistochemical analyses reveal that these neurons likely release acetylcholine in addition to serotonin and that exogenous and endogenous serotonin have opposing effects on olfactory responses. Finally, we show that activation of the entire serotonergic network, as opposed to only activation of those fibers innervating the antennal lobe, may be required for persistent serotonergic modulation of pheromone responses in the antennal lobe.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.