ArticleHypertension (Dallas, Tex. : 1979)2016
Regular Exercise Reduces Endothelial Cortical Stiffness in Western Diet-Fed Female Mice.
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Article in Hypertension (Dallas, Tex. : 1979), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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26citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Preclinical techniques to investigate exercise training in vascular pathophysiology.American journal of physiology. Heart and circulatory physiology · 2021Pooled it
- Expert consensus statement for basic research of animal exercise intervention studies in chronic disease prevention and treatment: A joint position paper of the Exercise Science branch of the Biophysical Society of China and the Metabolism and Genetics branch of the Genetics Society of China.Journal of sport and health science · 2025Article
- The Effect of Diet on Vascular Aging: A Narrative Review of the Available Literature.Life (Basel, Switzerland) · 2024Review
- Modulation of arterial intima stiffness by disturbed blood flow.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Brain Endothelial Cells Play a Central Role in the Development of Enlarged Perivascular Spaces in the Metabolic Syndrome.Medicina (Kaunas, Lithuania) · 2023Review
- Overview and New Insights into the Metabolic Syndrome: Risk Factors and Emerging Variables in the Development of Type 2 Diabetes and Cerebrocardiovascular Disease.Medicina (Kaunas, Lithuania) · 2023Review
- Ultrastructural Remodeling of the Blood-Brain Barrier and Neurovascular Unit by Lipopolysaccharide-Induced Neuroinflammation.International journal of molecular sciences · 2023Article
- Cystamine reduces vascular stiffness in Western diet-fed female mice.American journal of physiology. Heart and circulatory physiology · 2022Article
- Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice.American journal of physiology. Heart and circulatory physiology · 2021Article
- Guidelines for the measurement of vascular function and structure in isolated arteries and veins.American journal of physiology. Heart and circulatory physiology · 2021Review
- TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Exercise during pregnancy mitigates the adverse effects of maternal obesity on adult male offspring vascular function and alters one-carbon metabolism.Physiological reports · 2020Article
- LIMK (LIM Kinase) Inhibition Prevents Vasoconstriction- and Hypertension-Induced Arterial Stiffening and Remodeling.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Western diet induces renal artery endothelial stiffening that is dependent on the epithelial NaAmerican journal of physiology. Renal physiology · 2020Article
- Sexual Dimorphism in Obesity-Associated Endothelial ENaC Activity and Stiffening in Mice.Endocrinology · 2019Article
- Diet-Induced Obesity Promotes Kidney Endothelial Stiffening and Fibrosis Dependent on the Endothelial Mineralocorticoid Receptor.Hypertension (Dallas, Tex. : 1979) · 2019Article
- New insights into arterial stiffening: does sex matter?American journal of physiology. Heart and circulatory physiology · 2018Review
- Glycemic control by the SGLT2 inhibitor empagliflozin decreases aortic stiffness, renal resistivity index and kidney injury.Cardiovascular diabetology · 2018Article
- Arterial Stiffness in Hypertension: an Update.Current hypertension reports · 2018Review
- Beneficial Effects of Exercise on Subendothelial Matrix Stiffness are Short-Lived.Journal of biomechanical engineering · 2018Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Jaume PadillaFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Francisco I Ramirez-PerezFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Javad HabibiFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Brian BostickFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Annayya R AroorFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Melvin R HaydenFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Guanghong JiaFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Mona GarroFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Vincent G DeMarcoFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Camila ManriqueFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Frank W BoothFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
Luis A Martinez-LemusFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.).
James R SowersFrom the Department of Nutrition and Exercise Physiology (J.P., F.W.B.), Dalton Cardiovascular Research Center (J.P., F.I.R.-P., L.A.M.-L., J.R.S.), Department of Child Health (J.P.), Department of Biological Engineering (F.I.R.-P., L.A.M.-L.); Division of Cardiovascular Medicine, Department of Medicine (B.B.), Diabetes and Cardiovascular Research Center (J.H., A.R.A., M.R.H., G.J., M.G., V.G.D., C.M., J.R.S.), Department of Medical Pharmacology and Physiology (L.A.M.-L., J.R.S.), and Biomedical Sciences (F.W.B.), University of Missouri; and Research Service, Harry S. Truman Memorial Veterans' Hospital, Columbia, MO (J.R.S.). sowersj@health.missouri.edu.
Cardiovascular Research Center · BRUniversity of Missouri · US
Funding
Mechanisms of Microvascular Remodeling ProgressionR01HL088105 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MARTINEZ-LEMUS, LUIS A · 2009 to 2019
$3.3MANG II OPPOSES INS MEDIATED VASORELAXATION &GLU UTILZAR01HL073101 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SOWERS, JAMES RUSSELL · 2004 to 2013
$2.7MAng II and Overnutrition and Insulin resistance in Cardiovascular TissueR01HL107910 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SOWERS, JAMES RUSSELL · 2011 to 2015
$1.8MMineralocorticoid and estrogen receptor alpha signaling in the pathogenesis of vascular stiffness in insulin resistant femalesK08HL129074 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI MANRIQUE ACEVEDO, CAMILA MARGARITA · 2015 to 2019
$802kVascular Insulin Resistance in Obesity: Role of Endoplasmic Reticulum StressK01HL125503 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI PADILLA, JAUME · 2015 to 2018
$564kTargeting endoplasmic reticulum stress to correct vascular insulin resistance and glycemic dysregulation in diabetesR21DK105368 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI PADILLA, JAUME · 2015 to 2016
$422kInteractions of the RAAS and a Western Diet on Insulin Metabolic ActionsI01BX001981 · VA · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · PI LASTRA, GUIDO · 2013 to 2022
–BLRD VA I01 BX001981NHLBI NIH HHS K01 HL125503NHLBI NIH HHS K08 HL129074NHLBI NIH HHS R01 HL073101NHLBI NIH HHS R01 HL088105NHLBI NIH HHS R01 HL107910NIDDK NIH HHS R21 DK105368
Abstract
We recently showed that Western diet-induced obesity and insulin resistance promotes endothelial cortical stiffness in young female mice. Herein, we tested the hypothesis that regular aerobic exercise would attenuate the development of endothelial and whole artery stiffness in female Western diet-fed mice. Four-week-old C57BL/6 mice were randomized into sedentary (ie, caged confined, n=6) or regular exercise (ie, access to running wheels, n=7) conditions for 16 weeks. Exercise training improved glucose tolerance in the absence of changes in body weight and body composition. Compared with sedentary mice, exercise-trained mice exhibited reduced endothelial cortical stiffness in aortic explants (sedentary 11.9±1.7 kPa versus exercise 5.5±1.0 kPa; P<0.05), as assessed by atomic force microscopy. This effect of exercise was not accompanied by changes in aortic pulse wave velocity (P>0.05), an in vivo measure of aortic stiffness. In comparison, exercise reduced femoral artery stiffness in isolated pressurized arteries and led to an increase in femoral internal artery diameter and wall cross-sectional area (P<0.05), indicative of outward hypertrophic remodeling. These effects of exercise were associated with an increase in femoral artery elastin content and increased number of fenestrae in the internal elastic lamina (P<0.05). Collectively, these data demonstrate for the first time that the aortic endothelium is highly plastic and, thus, amenable to reductions in stiffness with regular aerobic exercise in the absence of changes in in vivo whole aortic stiffness. Comparatively, the same level of exercise caused destiffening effects in peripheral muscular arteries, such as the femoral artery, that perfuse the working limbs.
Indexed as
Sedentary BehaviorAnimalsCardiovascular DiseasesDiet, WesternDisease Models, AnimalEndothelium, VascularFemaleFemoral ArteryMiceMice, Inbred C57BLObesityPhysical Conditioning, AnimalRandom AllocationReference ValuesVascular Stiffnessanimal models of human diseasearterial stiffnessobesityphysical activityvascular biology
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