ArticleClinical physiology and functional imaging2018
Impact of abnormal cerebrovascular reactivity on BOLD fMRI: a preliminary investigation of moyamoya disease.
Article in Clinical physiology and functional imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 18 citations in OpenAlex.
- Persistent dysmorphology and dysfunction of the brain microvasculature following repeated trauma.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Longitudinal reproducibility of brain and spinal cord quantitative MRI biomarkers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Evaluation of the cerebrovascular reactivity in patients with Moyamoya Angiopathy by use of breath-hold fMRI: investigation of voxel-wise hemodynamic delay correction in comparison to [Neuroradiology · 2023Article
- Examining temporal features of BOLD-based cerebrovascular reactivity in clinical populations.Frontiers in neurology · 2023Article
- Correspondence between BOLD fMRI task response and cerebrovascular reactivity across the cerebral cortex.Frontiers in physiology · 2023Article
- Hemodynamic evaluation of patients with Moyamoya Angiopathy: comparison of resting-state fMRI to breath-hold fMRI and [Neuroradiology · 2022Article
- Application of DTI and fMRI in moyamoya disease.Frontiers in neurology · 2022Review
- Intraoperative local hemodynamic quantitative analysis of direct revascularization in patients with moyamoya disease.Neurosurgical review · 2021Article
- Article
- Static and dynamic functional connectivity analysis of cerebrovascular reactivity: An fMRI study.Brain and behavior · 2020Article
- Hypercapnic BOLD MRI compared to HNeuroImage. Clinical · 2019Article
- Impact of aberrant cerebral perfusion on resting-state functional MRI: A preliminary investigation of Moyamoya disease.PloS one · 2017Article
- The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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4 authors at 2 institutions in 1 country.
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Abstract
Blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) studies of patients with cerebrovascular disease have largely ignored the confounds associated with abnormal cerebral blood flow, vascular reactivity and neurovascular coupling. We studied BOLD fMRI activation and cerebrovascular reactivity in moyamoya disease. To characterize the impact of remote vascular demands on BOLD fMRI measurements, we varied the vascular territories engaged by manipulating the experimental task performed by the participants. Vascular territories affected by disease were identified using BOLD cerebrovascular reactivity. Preliminary evidence from two patients pre- and postrevascularization surgery and four controls indicates that neurovascular coupling in affected brain regions can be modulated by the task-related vascular demands in unaffected regions. In one patient studied, we observed that brain regions with improved cerebrovascular reactivity after surgery demonstrated normalized neurovascular coupling, that is the degree to which neurovascular coupling was modulated by task-related vascular demands was decreased. We propose that variations in task-dependent neurovascular coupling in patients with moyamoya disease are likely related to vascular steal. While preliminary, our findings are a proof of concept of the limitations of BOLD fMRI in cerebrovascular disease and suggest a role for assessment of cerebrovascular reactivity to improve interpretation of task-related BOLD fMRI activation.
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