ArticleNature microbiology2016
Genomic diversity of EPEC associated with clinical presentations of differing severity.
Article in Nature microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 91 citations in OpenAlex.
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- Novel marker genes for simultaneous detection of Salmonella, EHEC O157:H7, and Cronobacter.Scientific reports · 2026Article
- The accessory type III secretion system effectors collectively shape intestinal inflammatory infection outcomes.Gut microbes · 2025Article
- Genomic epidemiology of enteropathogenic Escherichia coli in southwestern Nigeria.PLoS neglected tropical diseases · 2025Article
- Straining to define a healthy microbiome.mSphere · 2025Review
- Genomic features of three major diarrhoeagenicMicrobial genomics · 2025Article
- Use of gastrointestinal syndromic multiplex molecular assays and detection ofJournal of clinical microbiology · 2025Article
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- The diverse virulence potential of atypical enteropathogenicFrontiers in microbiology · 2025Article
- Whole genome sequencing analysis of enteropathogenicJournal of veterinary science · 2025Article
- Expression of the locus of enterocyte effacement genes during the invasion process of the atypical enteropathogenicMicrobiology spectrum · 2024Article
- Phenotypic diversity of type III secretion system activity in enteropathogenicJournal of medical microbiology · 2024Article
- The pathogen-encoded signalling receptor Tir exploits host-like intrinsic disorder for infection.Communications biology · 2024Article
- Genetic and virulence characteristics of hybrid Shiga toxin-producing and atypical enteropathogenicFrontiers in microbiology · 2024Article
- Identification of a genomic cluster related to hypersecretion of intestinal mucus and mucinolytic activity of atypical enteropathogenicFrontiers in cellular and infection microbiology · 2024Article
- Article
- Genomic and Functional Characterization of Longitudinal Pseudomonas aeruginosa Isolates from Young Patients with Cystic Fibrosis.Microbiology spectrum · 2023Article
- Clinical and Bacterial Characteristics Associated with Glove and Gown Contamination by Carbapenem-Resistant Klebsiella pneumoniae in the Health Care Setting.Microbiology spectrum · 2023Article
Corrections and comments
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Authors and funding
18 authors at 10 institutions in 8 countries.
Funding
Abstract
Enteropathogenic Escherichia coli (EPEC) are diarrhoeagenic E. coli, and are a significant cause of gastrointestinal illness among young children in developing countries. Typical EPEC are identified by the presence of the bundle-forming pilus encoded by a virulence plasmid, which has been linked to an increased severity of illness, while atypical EPEC lack this feature. Comparative genomics of 70 total EPEC from lethal (LI), non-lethal symptomatic (NSI) or asymptomatic (AI) cases of diarrhoeal illness in children enrolled in the Global Enteric Multicenter Study was used to investigate the genomic differences in EPEC isolates obtained from individuals with various clinical outcomes. A comparison of the genomes of isolates from different clinical outcomes identified genes that were significantly more prevalent in EPEC isolates of symptomatic and lethal outcomes than in EPEC isolates of asymptomatic outcomes. These EPEC isolates exhibited previously unappreciated phylogenomic diversity and combinations of virulence factors. These comparative results highlight the diversity of the pathogen, as well as the complexity of the EPEC virulence factor repertoire.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.