ArticleNature microbiology2016
Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants.
Article in Nature microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 79 citations in OpenAlex.
- Parallel evolutionary trajectories rewire enteropathogenicGut microbes · 2026Article
- Characterisation of Typical Enteropathogenic Escherichia coli (tEPEC) and bfpA Genes From Five Bat Species Reveals Australian Pteropus Spp. Are Natural tEPEC Hosts.MicrobiologyOpen · 2026Article
- High-precision binary trait association on phylogenetic trees.Microbial genomics · 2026Article
- Genome on the move: emergence of hybrid atypical enteropathogenic/enteroaggregativeMicrobiology spectrum · 2026Article
- Exploration of the genomic diversity of third-generation cephalosporin-resistantMicrobial genomics · 2026Article
- Novel strains of typical enteropathogenicMicrobial genomics · 2025Article
- Genomic epidemiology of enteropathogenic Escherichia coli in southwestern Nigeria.PLoS neglected tropical diseases · 2025Article
- A foodborne outbreak caused by atypical enteropathogenicApplied and environmental microbiology · 2025Article
- The diverse virulence potential of atypical enteropathogenicFrontiers in microbiology · 2025Article
- Phenotypic diversity of type III secretion system activity in enteropathogenicJournal of medical microbiology · 2024Article
- Evolution of the pheV-tRNA integrated genomic island in Escherichia coli.PLoS genetics · 2024Article
- Identification of a genomic cluster related to hypersecretion of intestinal mucus and mucinolytic activity of atypical enteropathogenicFrontiers in cellular and infection microbiology · 2024Article
- Genetic Diversity and Expression of Intimin inMicroorganisms · 2023Article
- Identification and Evaluation of Pathogenic Genes (Reports of biochemistry & molecular biology · 2023Article
- Genomic diversity of non-diarrheagenic fecal Escherichia coli from children in sub-Saharan Africa and south Asia and their relatedness to diarrheagenic E. coli.Nature communications · 2023Article
- Enteropathogenic Escherichia coli (EPEC) expressing a non-functional bundle-forming pili (BFP) also leads to increased growth failure and intestinal inflammation in C57BL/6 mice.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Genomics and pathotypes of the many faces of Escherichia coli.FEMS microbiology reviews · 2022Article
- Enabling genomic island prediction and comparison in multiple genomes to investigate bacterial evolution and outbreaks.Microbial genomics · 2022Article
- Genomic Diversity, Virulence Gene, and Prophage Arrays of Bovine and Human Shiga Toxigenic and EnteropathogenicFrontiers in microbiology · 2022Article
- Genomic Analysis ofMicroorganisms · 2021Article
Corrections and comments
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Authors and funding
23 authors at 12 institutions in 9 countries.
Funding
Abstract
Atypical enteropathogenic Escherichia coli (aEPEC) is an umbrella term given to E. coli that possess a type III secretion system encoded in the locus of enterocyte effacement (LEE), but lack the virulence factors (stx, bfpA) that characterize enterohaemorrhagic E. coli and typical EPEC, respectively. The burden of disease caused by aEPEC has recently increased in industrialized and developing nations, yet the population structure and virulence profile of this emerging pathogen are poorly understood. Here, we generated whole-genome sequences of 185 aEPEC isolates collected during the Global Enteric Multicenter Study from seven study sites in Asia and Africa, and compared them with publicly available E. coli genomes. Phylogenomic analysis revealed ten distinct widely distributed aEPEC clones. Analysis of genetic variation in the LEE pathogenicity island identified 30 distinct LEE subtypes divided into three major lineages. Each LEE lineage demonstrated a preferred chromosomal insertion site and different complements of non-LEE encoded effector genes, indicating distinct patterns of evolution of these lineages. This study provides the first detailed genomic framework for aEPEC in the context of the EPEC pathotype and will facilitate further studies into the epidemiology and pathogenicity of EPEC by enabling the detection and tracking of specific clones and LEE variants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.