ArticleThe Journal of infectious diseases2016
Seasonal Influenza Vaccination of Children Induces Humoral and Cell-Mediated Immunity Beyond the Current Season: Cross-reactivity With Past and Future Strains.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Influenza vaccine effectiveness among primary and secondary school students in Shenzhen during the 2023/24 influenza season.Emerging microbes & infections · 2025Article
- Article
- Development of Influenza-Specific CD4 T Cell-Mediated Immunity in Children Following Inactivated Influenza Vaccination.Journal of the Pediatric Infectious Diseases Society · 2024Article
- Which influenza viruses will emerge following the SARS-CoV-2 pandemic?Influenza and other respiratory viruses · 2021Article
- Differences in Influenza-Specific CD4 T-Cell Mediated Immunity Following Acute Infection Versus Inactivated Vaccination in Children.The Journal of infectious diseases · 2021Article
- Influenza in Children.Cold Spring Harbor perspectives in medicine · 2021Review
- Differences in the influenza-specific CD4 T cell immunodominance hierarchy and functional potential between children and young adults.Scientific reports · 2019Article
- Influenza Vaccination: Effectiveness, Indications, and Limits in the Pediatric Population.Frontiers in pediatrics · 2019Review
- Effectiveness of influenza vaccination on influenza-associated hospitalisations over time among children in Hong Kong: a test-negative case-control study.The Lancet. Respiratory medicine · 2018Article
- An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers.Journal of visualized experiments : JoVE · 2017Article
- Differential Effects of Prior Influenza Exposures on H3N2 Cross-reactivity of Human Postvaccination Sera.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Correlation between infectious disease and soil radiation in Japan: an exploratory study using national sentinel surveillance data.Epidemiology and infection · 2017Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundInfluenza viruses gradually accumulate point mutations, reducing the effectiveness of prior immune protection.
methodsChildren aged 9-14 years received 2010-2011 trivalent inactivated influenza vaccine (TIV). Vaccination history, hemagglutination-inhibition (HI) titers, and cell-mediated immune responses were assessed to investigate the cross-reactivity with past and future influenza virus strains.
results2010-2011 TIV induced significant T-cell responses and HI titers of ≥160, with a fold-rise of ≥4 and titers of ≥100 maintained for >7 months in the majority of children. Pre-existing memory B cells in these children differentiated quickly to antibody-secreting cells to the new vaccine antigens. Children vaccinated in the previous year maintained high HI titers well into 2010, demonstrating elevated HI titers against A/Perth/16/2009, the future (in 2010-2011) H3N2 component. Prior vaccination enhanced CD8
conclusionsSeasonal influenza viruses continuously drift, which allows them to circumvent protective immunity, but conserved epitopes provide immunological cross-reactivity in children through either vaccination directly or through prime/boost in the prior influenza season.
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