ArticleLipids2016
Compositional Analysis of Wax Esters in Human Meibomian Gland Secretions by Direct Infusion Electrospray Ionization Mass Spectrometry.
Article in Lipids, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Stability and Compressibility of Tear Film Lipid Layer: Impact of Benzalkonium Chloride Presence.bioRxiv : the preprint server for biology · 2026Article
- Structural characterization of wax esters using ultraviolet photodissociation mass spectrometry.Analytical and bioanalytical chemistry · 2024Article
- Another Brick in the Wall of Tear Film Insights Added Through the Total Synthesis and Biophysical Profiling ofJournal of natural products · 2024Article
- Nonpolar Lipids Contribute to Midday Fogging During Scleral Lens Wear.Investigative ophthalmology & visual science · 2023Article
- Dynamic Changes in the Gene Expression Patterns and Lipid Profiles in the Developing and Maturing Meibomian Glands.International journal of molecular sciences · 2022Article
- Triacylglycerol lipidome from human meibomian gland epithelial cells: Description, response to culture conditions, and perspective on function.Experimental eye research · 2021Article
- Androgen and meibomian gland dysfunction: from basic molecular biology to clinical applications.International journal of ophthalmology · 2021Review
- Lipidomic analysis of meibomian gland secretions from the tree shrew: Identification of candidate tear lipids critical for reducing evaporation.Chemistry and physics of lipids · 2019Article
- Untargeted lipidomic analysis of human tears: A new approach for quantification of O-acyl-omega hydroxy fatty acids.The ocular surface · 2019Review
- Comprehensive shotgun lipidomics of human meibomian gland secretions using MS/MSJournal of lipid research · 2018Article
- Expression Profiling of Nonpolar Lipids in Meibum From Patients With Dry Eye: A Pilot Study.Investigative ophthalmology & visual science · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Wax esters (WE) are one of the predominant lipid types in human meibomian gland secretions (meibum) and account for 40-50 % of total meibum lipids. Recently, we managed to quantify 51 isomeric groups of intact WE in normal human meibum samples by direct infusion electrospray ionization mass spectrometry (ESI-MS), with each WE peak in the MS spectrum corresponding to one isomeric group (Chen et al, Invest Ophthalmol Vis Sci 54(8):5730-53, 2013). However, the information of the isomeric composition in each group was not obtained. In this study, tandem mass spectrometry (MS/MS) was applied to quantify relative amounts of these isomers using the intensities of the corresponding diagnostic ions after appropriate correction and normalization. This data was combined with the previous obtained mole fraction of each isomeric group to total WE in human meibum to determine the corresponding percentage of each isomer. A total of 23 of the most abundant WE peaks of different molecular weights (corresponding to 85.3 % of the total amount of WE) in human meibum were studied and resulted in quantification of 92 WE species. The quantitative information of composition of WE in human meibum will help better understand their role in the tear film.
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