ArticleMolecular plant pathology2017
Pex14/17, a filamentous fungus-specific peroxin, is required for the import of peroxisomal matrix proteins and full virulence of Magnaporthe oryzae.
Article in Molecular plant pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Building peroxisomes: perspectives on plant peroxins.Biochemical Society transactions · 2026Review
- VdPex30, a peroxisomal membrane protein, is involved in carbon metabolism, stress response, and pathogenicity ofMicrobiology spectrum · 2026Article
- LUCID: An Integrative Approach for Target Discovery and dsRNA Design in Plant Fungal Pathogens.Plant biotechnology journal · 2026Article
- Pex8, a Fungal Specific Peroxin, Regulates Peroxisome Biogenesis and Pathogenicity in the Cucumber Anthracnose FungusJournal of fungi (Basel, Switzerland) · 2026Article
- Characterization ofJournal of fungi (Basel, Switzerland) · 2026Article
- Fatty acids in filamentous pathogenic fungi: Multidimensional regulation and pathogenic mechanisms.Virulence · 2025Review
- Regulatory Mechanism of Peroxisome Number Reduction Caused byJournal of fungi (Basel, Switzerland) · 2023Article
- Fluorescent Labeling of Peroxisome and Nuclear inJournal of fungi (Basel, Switzerland) · 2023Article
- Article
- The Devastating Rice Blast Airborne PathogenPathogens (Basel, Switzerland) · 2023Review
- Article
- Transcriptional acclimation and spatial differentiation characterize drought response by the ectomycorrhizal fungus Suillus pungens.The New phytologist · 2022Article
- The essential role of fungal peroxisomes in plant infection.Molecular plant pathology · 2022Review
- MoWhi2 Mediates Mitophagy to Regulate Conidiation and Pathogenesis inInternational journal of molecular sciences · 2022Article
- Article
- The peroxins BcPex8, BcPex10, and BcPex12 are required for the development and pathogenicity ofFrontiers in microbiology · 2022Article
- Monitoring peroxisome dynamics using enhanced green fluorescent protein labeling inFrontiers in microbiology · 2022Article
- MrPEX33 is involved in infection-related morphogenesis and pathogenicity of Metarhizium robertsii.Applied microbiology and biotechnology · 2021Article
- Tolerance to Abiotic Factors of Microsclerotia and Mycelial Pellets FromFrontiers in fungal biology · 2021Article
- The Peroxisomal-CoA Synthetase MoPcs60 Is Important for Fatty Acid Metabolism and Infectious Growth of the Rice Blast Fungus.Frontiers in plant science · 2021Article
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10 authors.
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Abstract
Peroxisomes are ubiquitous organelles in eukaryotic cells that fulfil a variety of biochemical functions. The biogenesis of peroxisomes requires a variety of proteins, named peroxins, which are encoded by PEX genes. Pex14/17 is a putative recently identified peroxin, specifically present in filamentous fungal species. Its function in peroxisomal biogenesis is still obscure and its roles in fungal pathogenicity have not yet been documented. Here, we demonstrate the contributions of Pex14/17 in the rice blast fungus Magnaporthe oryzae (Mopex14/17) to peroxisomal biogenesis and fungal pathogenicity by targeting gene replacement strategies. Mopex14/17 has properties of both Pex14 and Pex17 with regard to its protein sequence. Mopex14/17 is distributed at the peroxisomal membrane and is essential for efficient peroxisomal targeting of proteins containing peroxisomal targeting signal 1. MoPEX19 deletion leads to the cytoplasmic distribution of Mopex14/17, indicating that the peroxisomal import of Pex14/17 is dependent on Pex19. The knockout mutants of MoPEX14/17 show reduced fatty acid utilization, reactive oxygen species (ROS) degradation and cell wall integrity. Moreover, Δmopex14/17 mutants show delayed conidial generation and appressorial formation, and a reduction in appressorial turgor accumulation and penetration ability in host plants. These defects result in a significant reduction in the virulence of the mutant. These data indicate that MoPEX14/17 plays a crucial role in peroxisome biogenesis and contributes to fungal development and pathogenicity.
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