ArticleMolecular medicine reports2016
Ameliorative effects of Artemisia argyi Folium extract on 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like lesions in BALB/c mice.
Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Management of Atopic Dermatitis Via Oral and Topical Administration of Herbs in Murine Model: A Systematic Review.Frontiers in pharmacology · 2022Pooled it
- KoreanFrontiers in pharmacology · 2026Review
- Optimization of Its Preparation and Evaluation of Fresh and Tender Leaves ofFoods (Basel, Switzerland) · 2025Article
- Anti-Biofilm Properties of Cell-Free Supernatant fromMicroorganisms · 2025Article
- Relieving Effect ofAntioxidants (Basel, Switzerland) · 2025Article
- A review of the research progress on Artemisia argyi Folium: botany, phytochemistry, pharmacological activities, and clinical application.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Elucidation of Anti-Obesity Mechanisms of Phenolics inLife (Basel, Switzerland) · 2024Article
- Evaluation of Artemisia dubia folium extract-mediated immune efficacy through developing a murine model for acute and chronic stages of atopic dermatitis.Laboratory animal research · 2024Article
- Comprehensive Review on Phytoconstituents-based Nanomedicine for the Treatment of Atopic Dermatitis.Current pharmaceutical biotechnology · 2024Review
- Anti-Inflammatory Herbal Extracts and Their Drug Discovery Perspective in Atopic Dermatitis.Biomolecules & therapeutics · 2024Review
- Secondary Metabolites and Their Cytotoxic Activity ofMolecules (Basel, Switzerland) · 2022Article
- Ta-Xi-San Suppresses Atopic Dermatitis Involved in Multitarget Mechanism Using Experimental and Network Pharmacology Analysis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- The Essential Oil ofFrontiers in pharmacology · 2021Article
- Caffeoyl-Prolyl-Histidine Amide Inhibits Fyn and Alleviates Atopic Dermatitis-Like Phenotypes via Suppression of NF-κB Activation.International journal of molecular sciences · 2020Article
- Ameliorative effects of sea buckthorn oil on DNCB induced atopic dermatitis model mice via regulation the balance of Th1/Th2.BMC complementary medicine and therapies · 2020Article
- A prospective review of the health-promoting potential of Jing Si Herbal Tea.Tzu chi medical journalReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artemisia argyi Folium has been used to treat skin diseases, including eczema and dermatitis, in South Korean medicine. The present study investigated the curative effects of Artemisia argyi Folium extract (AAFE) on 2,4‑dinitrochlorobenzene (DNCB)‑induced atopic dermatitis (AD)‑like skin lesions in a BALB/c mouse model. Briefly, the dorsal skin of the BALB/c mice was sensitized three times with DNCB, whereas the ears were challenged twice. Repeated treatment with DNCB induced AD‑like lesions. The effects of AAFE on AD‑like lesions were evaluated by clinical observation, histopathological analysis, immunohistochemistry and enzyme‑linked immunosorbent assay. In addition, reverse transcription‑polymerase chain reaction and western blotting were performed. Treatment with AAFE reduced AD‑like lesions, as determined by clinical observation, histopathological analysis, and detection of the serum levels of histamine, immunoglobulin E and cytokines. With regards to its mechanism of action, AAFE inhibited the phosphorylation of Lck/yes‑related novel tyrosine kinase (Lyn), spleen tyrosine kinase (Syk), mitogen‑activated protein kinases (MAPKs), phosphoinositide 3‑kinase (PI3K)/Akt and IκBα, which have essential roles in the production of various cytokines in lymph nodes. The suppressive activity of AAFE may be due to the inhibition of a series of immunopathological events, including the release of proinflammatory cytokines. The results of the present study strongly suggest that AAFE exerts an anti‑AD effect by inhibiting the Lyn, Syk, MAPKs, PI3K/Akt and IκBα pathways. Therefore, AAFE may be considered an effective herbal remedy for the treatment of AD.
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