SynthesisPloS one2016
The Magnitude of the Association between Human Papillomavirus and Oral Lichen Planus: A Meta-Analysis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing bias in the causal role of HPV in oral cancer: A systematic review and meta-analysis.Oral diseases · 2024Pooled it
- Comorbidity in Lichen Planus: A Retrospective Population-Based Case-Control Study in Sweden.Life (Basel, Switzerland) · 2026Article
- Association between Epstein Barr virus and Oral Lichen Planus clinical phenotypes and p53 expression.Scientific reports · 2025Article
- Cell-mediated mucositis of the oral cavity: narrative review on etiology, clinico-pathological aspects and malignant transformation.Pathologica · 2025Review
- Oral Squamous Cell Carcinoma in Atrophic-Erosive Lichen Planus: 10-Year Rehabilitative Case Report.Case reports in dentistry · 2025Article
- Oral Lichen Planus: Clinical Presentation, Demographic Characteristics, and Risk Factors in a Retrospective Study of 186 Polish Patients.Journal of clinical medicine · 2024Article
- Function of unconventional T cells in oral lichen planus revealed by single-cell RNA sequencing.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Evaluation of the Role of Oral Microbes in Pathogenesis of Oral Lichen Planus.Journal of pharmacy & bioallied sciences · 2024Article
- Human Papillomavirus in Oral Lichen Planus: Is There an Association? A Meta-Analysis.Journal of clinical medicine · 2024Review
- Oral Lichen Planus: An Update on Diagnosis and Management.American journal of clinical dermatology · 2024Review
- The association between high-risk human papillomavirus and oral lichen planus.Clinical and experimental dental research · 2023Article
- Oral Papillomatosis: Its Relation with Human Papilloma Virus Infection and Local Immunity-An Update.Medicina (Kaunas, Lithuania) · 2022Review
- PCR-based Evaluation of Human Papillomavirus Genotypes in Oral Lichen Planus.Journal of pharmacy & bioallied sciences · 2022Article
- Review
- Efficacy of Systemic Acyclovir as Adjuvant Therapy for Oral Lichen Planus.The American journal of case reports · 2021Article
- Comparison of p53, HSP90, E-cadherin and HPV in oral lichen planus and oral squamous cell carcinoma.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021Article
- Oral lichen planus: a microbiologist point of view.International microbiology : the official journal of the Spanish Society for Microbiology · 2021Review
- High Prevalence of Human Papillomavirus Type 18 in Oral Potentially Malignant Disorders in Thailand.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- [Squamous cell carcinoma arising in oral lichen planus : Report of two cases].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2020Article
- Oral lichen planus: a novel staging and algorithmic approach and all that is essential to know.F1000Research · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of human papilloma virus (HPV) in oral lichen planus (OLP) is controversial.
objectivesThe primary aim of the current study is to calculate the pooled risk estimates of HPV infection in OLP when compared with healthy controls.
methodsBibliographic searches were conducted in three electronic databases. Articles on the association between HPV and OLP were selected from case-control studies or cross-sectional studies, following predefined criteria. Pooled data were analyzed by calculating odds ratios (OR) and 95% confidence interval (CI).
resultsOf the 233 publications identified, 22 case-control studies met the inclusion criteria. Collectively, 835 cases and 734 controls were available for analysis. The summary estimate showed that OLP patients have significantly higher HPV prevalence (OR: 6.83; 95% CI: 4.15-11.27) than healthy controls. In subgroup analyses, the association of HPV and OLP varied significantly by geographic populations. The ORs ranged from 2.43 to 132.04. The correlation of HPV and erosive-atrophic oral lichen planus (EA-OLP) (OR: 9.34) was comparable and well above that of HPV and non-EA-OLP (OR: 4.32). Among HPV genotypes, HPV 16 showed an extremely strong association with OLP (OR: 11.27), and HPV 18 showed a relatively strong one (OR: 6.54).
conclusionIn conclusion, a significant association was found between HPV and OLP. The strength of the association varied across geographic populations, clinical types of OLP, and HPV genotypes. The results suggest that HPV might play an important causal role in OLP and in its malignant to progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.