Evidence map›Paper›PMID 27571306›Full record

ArticleClinical and experimental immunology2016

Modulation of autoimmune arthritis severity in mice by apolipoprotein E (ApoE) and cholesterol.

P Alvarez, F Genre, M Iglesias, J J Augustin, E Tamayo, J C Escolà-Gil, B Lavín, F Blanco-Vaca, R Merino, J Merino

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

P AlvarezInstituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas-Universidad de Cantabria-SODERCAN, Santander, Spain.
F GenreDepartamento de Biología Molecular-IDIVAL Universidad de Cantabria, Santander, Spain.
M IglesiasDepartamento de Biología Molecular-IDIVAL Universidad de Cantabria, Santander, Spain.
J J AugustinInstituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas-Universidad de Cantabria-SODERCAN, Santander, Spain.
E TamayoDepartamento de Biología Molecular-IDIVAL Universidad de Cantabria, Santander, Spain.
J C Escolà-GilInstitut d'Investigacions Biomèdiques (IIB) Sant Pau, Barcelona, Spain, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain.
B LavínServicio de Análisis Clínicos, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
F Blanco-VacaInstitut d'Investigacions Biomèdiques (IIB) Sant Pau, Barcelona, Spain, Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain, CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain.
R MerinoInstituto de Biomedicina y Biotecnología de Cantabria, Consejo Superior de Investigaciones Científicas-Universidad de Cantabria-SODERCAN, Santander, Spain.
J MerinoDepartamento de Biología Molecular-IDIVAL Universidad de Cantabria, Santander, Spain.
Instituto de Investigación Marqués de Valdecilla · ESUniversidad de Cantabria · ESCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESConsejo Superior de Investigaciones Científicas · ESMarqués de Valdecilla University Hospital · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Apolipoprotein E (ApoE) deficiency promoted an exacerbation of autoimmune arthritis in mice by inducing proinflammatory immune responses. In this study we analysed the contribution of hypercholesterolaemia and/or the absence of ApoE anti-inflammatory properties, unrelated to its function in the control of cholesterol metabolism, towards the acceleration of arthritis in these mutant animals. The induction and severity of collagen type II-induced arthritis (CIA) were compared for B10.RIII wild-type (WT), B10.RIII.ApoE

Indexed as

ImmunomodulationAnimalsApolipoproteins EArthritis, ExperimentalAutoimmune DiseasesBiomarkersCholesterolCholesterol, HDLDisease Models, AnimalGenetic Association StudiesHypercholesterolemiaMiceMice, KnockoutMutationSeverity of Illness IndexApolipoproteins EBiomarkersCholesterolCholesterol, HDLApoEcollagen type II-induced arthritishypercholesterolaemiaLDLR

Identifiers

PMID27571306
PMCPMC5108071
OpenAlexW2523174015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.