ReviewAnnals of the New York Academy of Sciences2016
A new perspective on mechanisms governing skeletal complications in type 1 diabetes.
Review in Annals of the New York Academy of Sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Panx1 and P2X7R are associated with impaired skeletal health and delayed bone development in early onset of type 1 diabetes.Frontiers in endocrinology · 2026Article
- Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta-catenin from Forkhead box O to T cell factor interaction.Birth defects research · 2022Article
- Pancreas deficiency modifies bone development in the ovine fetus near term.The Journal of endocrinology · 2021Article
- Lower estimated bone strength and impaired bone microarchitecture in children with type 1 diabetes.BMJ open diabetes research & care · 2020Article
- Peripheral Neuropathy as a Component of Skeletal Disease in Diabetes.Current osteoporosis reports · 2019Review
- Role of pannexin 1 channels in load-induced skeletal response.Annals of the New York Academy of Sciences · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
This review focuses on bone mechanobiology in type 1 diabetes (T1D), an area of research on diabetes-associated skeletal complications that is still in its infancy. We first provide a brief overview of the deleterious effects of diabetes on the skeleton and of the knowledge gained from studies with rodent models of T1D. Second, we discuss two specific hallmarks of T1D, low insulin and high glucose, and address the extent to which they affect skeletal health. Third, we highlight the mechanosensitive nature of bone tissue and the importance of mechanical loading for bone health. We also summarize recent advances in bone mechanobiology that implicate osteocytes as the mechanosensors and major regulatory cells in the bone. Finally, we discuss recent evidence indicating that the diabetic bone is "deaf" to mechanical loading and that osteocytes are central players in mechanisms that lead to bone loss in T1D.
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Registered trials
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