ReviewEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2017
Adiposity, breast density, and breast cancer risk: epidemiological and biological considerations.
Review in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Article
- Breast imaging recommendations for young females (age < 40 years) with ≥ 20% lifetime breast cancer risk: practice patterns at a specialized clinic.Breast cancer research and treatment · 2025Article
- Central and peripheral adiposity and premenopausal breast cancer risk: a pooled analysis of 440,179 women.Breast cancer research : BCR · 2025Article
- Mammographic Density in Relation to Breast Cancer Risk Factors among Chinese Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Mammographic features differ with body composition in women with breast cancer.European radiology · 2025Article
- Lifecourse Growth and Development Determinants of Mammographic Density in Black Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Oxygen, angiogenesis, cancer and immune interplay in breast tumour microenvironment: a computational investigation.Royal Society open science · 2024Article
- Assessing Fat Grafting in Breast Surgery: A Narrative Review of Evaluation Techniques.Journal of clinical medicine · 2024Review
- Dense breast tissue in screened postmenopausal women: Prevalence and determinants.Saudi medical journal · 2024Article
- Association between Inflammatory Dietary Pattern and Mammographic Features.The Journal of nutrition · 2024Article
- Plasma C-peptide mammographic features and risk of breast cancer.NPJ breast cancer · 2024Article
- An analysis of the association between breast density and body mass index with breast cancer molecular subtypes in early breast cancer: data from a Spanish population.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Article
- Temporal changes in mammographic breast density and breast cancer risk among women with benign breast disease.Breast cancer research : BCR · 2024Article
- Physical Activity and Mammographic Density in Japanese Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Cigarette smoking and mammographic breast density in post-menopausal women from the EPIC Florence cohort.Frontiers in oncology · 2024Article
- Development and evaluation of a method to assess breast cancer risk using a longitudinal history of mammographic density: a cohort study.Breast cancer research : BCR · 2023Article
- Adipose-enriched peri-tumoral stroma, in contrast to myofibroblast-enriched stroma, prognosticates poorer survival in breast cancers.NPJ breast cancer · 2023Article
- Prenatal airborne polycyclic aromatic hydrocarbon exposure, altered regulation of peroxisome proliferator-activated receptor gamma (Ppar)γ, and links with mammary cancer.Environmental research · 2023Article
- Studying the association between longitudinal mammographic density measurements and breast cancer risk: a joint modelling approach.Breast cancer research : BCR · 2023Article
- Lifetime changes in body fatness and breast density in postmenopausal women: the FEDRA study.Breast cancer research : BCR · 2023Article
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Authors and funding
4 authors.
Funding
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Abstract
Excess total body fat and abdominal adipose tissue are recognized risk factors for metabolic diseases but also for some types of cancers, including breast cancer. Several biological mechanisms in connection with local and systemic effects of adiposity are believed to be implicated in breast cancer development, and may involve breast fat. Breast adipose tissue can be studied through mammography by looking at breast density features such as the nondense area mainly composed of fat, or the percent breast density, which is the proportion of fibroglandular tissue in relation to fat. The relation between adiposity, breast density features, and breast cancer is complex. Studies suggest a paradoxical association as adiposity and absolute nondense area correlate positively with each other, but in contrast to adiposity, absolute nondense area seems to be associated negatively with breast cancer risk. As breast density is one of the strongest risk factors for breast cancer, it is therefore critical to understand how these factors interrelate. In this review, we discuss these relations by first presenting how adiposity measurements and breast density features are linked to breast cancer risk. Then, we used a systematic approach to capture the literature to review the relation between adiposity and breast density features. Finally, the role of adipose tissue in carcinogenesis is discussed briefly from a biological perspective.
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