ArticleThe American journal of pathology1989
The role of fibronectin in the development of experimental amyloidosis. Evidence of immunohistochemical codistribution and binding property with serum amyloid protein A.
Article in The American journal of pathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 39 citations in OpenAlex.
- Amyloid in the cardiovascular system: a review.Journal of clinical pathology · 2005Review
- Linkage of protection against amyloid fibril formation in the mouse to a single, autosomal dominant gene.The Journal of experimental medicine · 1995Article
- Inhibitory effects of adhesion oligopeptides on the invasion of squamous carcinoma cells with special reference to implication of alpha v integrins.Journal of cancer research and clinical oncology · 1995Article
- Characterization of proteoglycans associated with mouse splenic AA amyloidosis.The Biochemical journal · 1994Article
- The expression of invasive behavior of differentiated squamous carcinoma cell line evaluated by an in vitro invasion model.Japanese journal of cancer research : Gann · 1993Article
- Fibronectin and basement membrane components in renal amyloid deposits in patients with primary and secondary amyloidosis.Clinical and experimental immunology · 1991Article
- High molecular weight glycosaminoglycans in AA type amyloid fibril extracts from human liver.Annals of the rheumatic diseases · 1991Article
- Amyloid resistance in A/J mice is not determined by genetic variants at, or close to, the serum amyloid P component locus.Clinical and experimental immunology · 1991Article
- Major acute-phase reactant synthesis during chronic inflammation in amyloid-susceptible and -resistant mouse strains.Inflammation · 1991Article
- Microfilamentous type VI collagen in the hyalinized stroma of the hypertrophied ligamentum flavum.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Article
- Left ventriculotomy of the heart: tissue repair and localization of collagen types I, II, III, IV, V, VI and fibronectin.Virchows Archiv. A, Pathological anatomy and histopathology · 1990Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Azocasein-induced amyloid A (AA) amyloidosis in CBA/K1Jms mice was investigated to elucidate a preference of serum amyloid A (SAA) deposition in the spleen. By indirect immunofluorescence using anti-SAA/AA antibodies the initial deposition of SAA/AA was recognized in the marginal zone of spleen at 20 days after azocasein injection. Indirect immunofluorescence using anti-fibronectin antibodies also showed meshwork positivity in the corresponding area more intensely than that in controls. Immunoelectron microscopy using anti-SAA/AA revealed the presence of positively stained flocculent materials on cell surfaces of macrophages in the marginal area in addition to amyloid fibril. The tissue fibronectin rapidly increased in the spleen and maintained 10 times more than that of controls until the 20th day. Binding assay of SAA on frozen sections revealed the presence of SAA-binding substances in the perifollicular area. Affinity chromatographic assay showed fibronectin have a binding capacity to SAA1 and SAA2. By binding assay on the microtiter plate, SAA had more affinity to fibronectin than those of heparan sulfate, collagen type I, or serum amyloid P component. These results indicate that fibronectin plays an important role in the development of amyloidosis by working as a linking protein between SAA and the cell surface of macrophages.
Indexed as
Identifiers
2757120PMC1879956W222177780What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.