ArticleThe American journal of pathology1989
Structural changes in the megakaryocytes of patients infected with the human immune deficiency virus (HIV-1).
Article in The American journal of pathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 107 citations in OpenAlex.
- Anti-GPIIIa antibody and CD4 count identify an autoimmune-enriched phenotype of HIV-associated thrombocytopenia: development and internal validation of a clinical nomogram.Frontiers in immunology · 2026Article
- TGFβ-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Prevalence and associated factors of thrombocytopenia among HAART-naive HIV-positive patients at Gondar University Hospital, northwest Ethiopia.BMC research notes · 2014Article
- HIV infection, antiretroviral therapy initiation and longitudinal changes in biomarkers of organ function.Current HIV research · 2014Article
- Platelet activation and platelet-monocyte aggregate formation contribute to decreased platelet count during acute simian immunodeficiency virus infection in pig-tailed macaques.The Journal of infectious diseases · 2013Article
- Effects of human immunodeficiency virus on the erythrocyte and megakaryocyte lineages.World journal of virology · 2013Review
- Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.The Journal of experimental medicine · 2011Article
- HIV and SIV Associated Thrombocytopenia: An Expanding Role for Platelets in the Pathogenesis of HIV.Drug discovery today. Disease mechanisms · 2011Article
- Review
- Pathobiology of secondary immune thrombocytopenia.Seminars in hematology · 2009Review
- Review
- The end is just the beginning: megakaryocyte apoptosis and platelet release.International journal of hematology · 2001Review
- Platelet production in the pulmonary capillary bed: new ultrastructural evidence for an old concept.The American journal of pathology · 2000Article
- Distinct human immunodeficiency virus strains in the bone marrow are associated with the development of thrombocytopenia.Journal of virology · 1999Article
- Simian immunodeficiency virus infection of macaque bone marrow macrophages correlates with disease progression in vivo.The American journal of pathology · 1991Article
- Autoantibodies against peripheral blood cells appear early in HIV infection and their prevalence increases with disease progression.Clinical and experimental immunology · 1990Article
- Megakaryocytes of human immunodeficiency virus-infected individuals express viral RNA.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Although immune mechanisms are known to be partially responsible for the thrombocytopenia of patients infected with HIV-1, an understanding of the mechanism underlying this disorder is incomplete. A casual observation that bone marrow biopsies of HIV-infected individuals seem to exhibit an unusually large number of denuded megakaryocyte nuclei (DN-MK) prompted a study comparing MK of 20 HIV-seropositive individuals with those of 10 patients with HIV-negative idiopathic thrombocytopenic purpura and 10 hematologically normal subjects. In normal marrows the number of DN-MK average 2.1 +/- 0.5 SE per 10 low power field. In patients with ITP the average number was 6.5 +/- 1.4 SEM, whereas HIV-ITP marrows had an average of 42.5 +/- 3.7 SEM. Electron microscopy of AIDS megakaryocytes exhibited ballooning of the peripheral zone to an extent not seen by us in any other myelodysplastic syndromes. These observations support the concept that the pathophysiology affecting MK/platelets in HIV-infection should not be equated with the destructive process underlying other immune thrombocytopenias.
Indexed as
Identifiers
2757119PMC1879955W148608904What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.